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Bisphenol B has a binding affinity for estrogen receptors.Drospirenone site |Product information|CAS Number: 859-18-7|Molecular Weight: 443.00|Formula: C18H35ClN2O6S|Synonym:|Lincocin|U-10149A|U10149A|U 10149A|Chemical Name: (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride|Smiles: Cl.C[C@@H](O)[C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O|InChiKey: POUMFISTNHIPTI-BOMBIWCESA-N|InChi: InChI=1S/C18H34N2O6S.PMID:33001710 ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.|Product information|CAS Number: 68786-66-3|Molecular Weight: 359.66|Formula: C14H9Cl3N2OS|Synonym:|Fasinex|CGA89317|Egaten|Endex-K|Chemical Name: 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole|Smiles: CSC1NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N=1|InChiKey: NQPDXQQQCQDHHW-UHFFFAOYSA-N|InChi: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson’s disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application.Droxidopa Purity GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.|Product information|CAS Number: 76778-22-8|Molecular Weight: 414.58|Formula: C28H34N2O|Synonym:|GBR12935|GBR-12935|Chemical Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine|Smiles: C(CCN1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1)C1C=CC=CC=1|InChiKey: RAQPOZGWANIDQT-UHFFFAOYSA-N|InChi: InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Telmisartan Biological Activity |Shelf Life: ≥12 months if stored properly.PMID:32639854 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Rimantadine is an orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection.Pretomanid Technical Information When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. Both rimantadine and the similar drug amantadine are derivates of adamantane.|Product information|CAS Number: 1501-84-4|Molecular Weight: 215.76|Formula: C12H22ClN|Synonym:|Flumadine hydrochloride|Chemical Name: 1-(adamantan-1-yl)ethan-1-amine hydrochloride|Smiles: Cl.PMID:33252208 CC(N)C12CC3CC(C1)CC(C2)C3|InChiKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N|InChi: InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.|Product information|CAS Number: 290821-39-5|Molecular Weight: 678.85|Formula: C37H58O11|Chemical Name: (2R,3S,4R,7R,9S,12R,14R,16R,17R,18R,19R,21R,22S)-2-hydroxy-22-(2-hydroxypropan-2-yl)-3,8,8,17,19-pentamethyl-9-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-23,24-dioxaheptacyclo[19.2.1.0¹,¹⁸.0³,¹⁷.0⁴,¹⁴.0⁷,¹².0¹²,¹⁴]tetracosan-16-yl acetate|Smiles: C[C@@H]1C[C@H]2OC3(O[C@@H]2C(C)(C)O)[C@H]1[C@@]1(C)[C@@H](C[C@@]24C[C@]52CC[C@H](O[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC[C@H]4[C@]1(C)[C@H]3O)OC(C)=O|InChiKey: HZIBYJCDCHVSPK-GKLVOFDRSA-N|InChi: InChI=1S/C37H58O11/c1-17-13-20-28(32(5,6)43)48-37(47-20)27(17)34(8)24(45-18(2)38)14-36-16-35(36)12-11-23(46-29-26(41)25(40)19(39)15-44-29)31(3,4)21(35)9-10-22(36)33(34,7)30(37)42/h17,19-30,39-43H,9-16H2,1-8H3/t17-,19+,20-,21+,22+,23+,24-,25+,26-,27-,28+,29+,30-,33-,34-,35-,36+,37?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Obiltoxaximab Data Sheet |Shelf Life: ≥12 months if stored properly.PMID:32809360 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor).Ryanodine Cancer Bornyl acetate possesses anti-cancer activity.|Product information|CAS Number: 76-49-3|Molecular Weight: 196.29|Formula: C12H20O2|Chemical Name: (1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.PMID:33249548 2.1]heptan-2-yl acetate|Smiles: CC1(C)[C@@H]2C[C@@H](OC(C)=O)[C@@]1(C)CC2|InChiKey: KGEKLUUHTZCSIP-HOSYDEDBSA-N|InChi: InChI=1S/C12H20O2/c1-8(13)14-10-7-9-5-6-12(10,4)11(9,2)3/h9-10H,5-7H2,1-4H3/t9-,10+,12+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.33 mg/mL (424.52 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Bornyl acetate is characterized as one of the most important odorants of fresh ginger juice, as it exhibits one of the highest FD factors. Bornyl acetate is also identified as playing very important sensory roles in the aroma of fresh Japanese ginger. Bornyl acetate (0-96 μM) induces dose-dependent growth inhibitory efects on human gastric cancer cells in vitro. Combined effect of Bornyl acetate (48 μM) and 5-FU on SGC-7901 human gastric cancer cell death via apoptosis.|References:|Pang X, et al. Identification of Ginger (Zingiber officinale Roscoe) Volatiles and Localization of Aroma-Active Constituents by GC-Olfactometry. J Agric Food Chem. 2017 May 24;65(20):4140-4145.Juan Li, et al. Synergistic enhancement of the antitumor activity of 5-fuorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action. J BUON. Jan-Feb 2016;21(1):108-17.Products are for research use only. Not for human use.|

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DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.|Product information|CAS Number: 346692-04-4|Molecular Weight: 307.38|Formula: C16H18FNO2S|Chemical Name: N-(4-butylphenyl)-4-fluorobenzene-1-sulfonamide|Smiles: CCCCC1C=CC(=CC=1)NS(=O)(=O)C1C=CC(F)=CC=1|InChiKey: CNGHPXKWPGIDSK-UHFFFAOYSA-N|InChi: InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (325.33 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Teropavimab} MedChemExpress|{Teropavimab} HIV|{Teropavimab} Activator|{Teropavimab} Technical Information|{Teropavimab} Description|{Teropavimab} custom synthesis} |Shelf Life: ≥360 days if stored properly.PMID:33207974 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.|References:|Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563.Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158.Products are for research use only. Not for human use.|

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GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).|Product information|CAS Number: 109053-09-0|Molecular Weight: 711.81|Formula: C31H53N9O10|Chemical Name: (2S)-2-{2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-4-methylpentanamido]acetamido}-3-methylpentanamido]propanamido]acetamido}-4-carbamoylbutanoic acid|Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O|InChiKey: BLNMYSBCIVAVFK-PFZXUFBWSA-N|InChi: InChI=1S/C31H53N9O10/c1-6-17(4)26(30(48)36-18(5)27(45)34-14-23(42)37-19(31(49)50)9-10-22(33)41)39-24(43)15-35-28(46)20(12-16(2)3)38-29(47)21-8-7-11-40(21)25(44)13-32/h16-21,26H,6-15,32H2,1-5H3,(H2,33,41)(H,34,45)(H,35,46)(H,36,48)(H,37,42)(H,38,47)(H,39,43)(H,49,50)/t17-,18-,19-,20-,21-,26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bardoxolone} medchemexpress|{Bardoxolone} Necroptosis|{Bardoxolone} Protocol|{Bardoxolone} In Vitro|{Bardoxolone} manufacturer|{Bardoxolone} Cancer} |Shelf Life: ≥12 months if stored properly.{{Fmoc-Ser(tBu)-OH} medchemexpress|{Fmoc-Ser(tBu)-OH} {Amino Acid Derivatives}|{Fmoc-Ser(tBu)-OH} Activator|{Fmoc-Ser(tBu)-OH} Protocol|{Fmoc-Ser(tBu)-OH} Formula|{Fmoc-Ser(tBu)-OH} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32490699 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization.|Products are for research use only. Not for human use.|

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Product information|CAS Number: 352323-25-2|Molecular Weight: 379.52|Formula: C16H17KN2O4S|Chemical Name: potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{2-[(2,3,4,5,6-²H₅)phenyl](2,2-²H₂)acetamido}-4-thia-1-azabicyclo[3.{{Hirudin} MedChemExpress|{Hirudin} Apoptosis|{Hirudin} Technical Information|{Hirudin} Data Sheet|{Hirudin} manufacturer|{Hirudin} Autophagy} 2.{{Rucaparib} MedChemExpress|{Rucaparib} Epigenetics|{Rucaparib} Technical Information|{Rucaparib} References|{Rucaparib} custom synthesis|{Rucaparib} Epigenetics} 0]heptane-2-carboxylate|Smiles: [K+].PMID:32310431 [2H]C([2H])(C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1C([2H])=C([2H])C([2H])=C([2H])C=1[2H]|InChiKey: IYNDLOXRXUOGIU-RSWIJXEESA-M|InChi: InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1/i3D,4D,5D,6D,7D,8D2;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).|Product information|CAS Number: 75168-11-5|Molecular Weight: 472.50|Formula: C26H38BrN3|Chemical Name: 3,6-bis(dimethylamino)-10-nonylacridin-10-ium bromide|Smiles: [Br-].CCCCCCCCC[N+]1C2=CC(=CC=C2C=C2C=CC(=CC=12)N(C)C)N(C)C|InChiKey: DRBHTUDHPPBMCD-UHFFFAOYSA-M|InChi: InChI=1S/C26H38N3.BrH/c1-6-7-8-9-10-11-12-17-29-25-19-23(27(2)3)15-13-21(25)18-22-14-16-24(28(4)5)20-26(22)29;/h13-16,18-20H,6-12,17H2,1-5H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (52.{{Dolutegravir} medchemexpress|{Dolutegravir} Metabolic Enzyme/Protease|{Dolutegravir} Purity & Documentation|{Dolutegravir} Formula|{Dolutegravir} custom synthesis|{Dolutegravir} Cancer} 91 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm) which can be used to quantify the cardiolipin in isolated mitochondria.{{Phosphatidylethano lamine} medchemexpress|{Phosphatidylethano lamine} Metabolic Enzyme/Protease|{Phosphatidylethano lamine} Technical Information|{Phosphatidylethano lamine} Data Sheet|{Phosphatidylethano lamine} supplier|{Phosphatidylethano lamine} Cancer} when Acridine Orange 10-Nonyl Bromide interacts with cardiolipin, the dye excitation and emission wave lengths shift from 496 and 525 nm to 450 and 640 nm, respectively.PMID:33125288 Increasing amounts of cardiolipin (0 to 30 μM) and other acidic phospholipids in thin-walled vesicles added to Acridine Orange 10-Nonyl Bromide (45 μM) changes the red fluorescence emission measured at 640 nm according to the liposome composition.|Products are for research use only. Not for human use.|

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HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.|Product information|CAS Number: 111374-21-1|Molecular Weight: 260.26|Formula: C10H12N8O|Chemical Name: 6-(pyrrolidin-1-yl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyrazine-2-carboxamide|Smiles: O=C(NC1N=NNN=1)C1=CN=CC(=N1)N1CCCC1|InChiKey: LUJDHCXCWJFNOJ-UHFFFAOYSA-N|InChi: InChI=1S/C10H12N8O/c19-9(13-10-14-16-17-15-10)7-5-11-6-8(12-7)18-3-1-2-4-18/h5-6H,1-4H2,(H2,13,14,15,16,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clavulanate} site|{Clavulanate} Antibiotic|{Clavulanate} Biological Activity|{Clavulanate} In Vitro|{Clavulanate} manufacturer|{Clavulanate} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33156798 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea. HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.|Products are for research use only. Not for human use.|

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3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals.|Product information|CAS Number: 2304-89-4|Molecular Weight: 406.56|Formula: C24H38O5|Chemical Name: (4R)-4-[(1R,3aS,3bR,4R,5aR,9aS,9bS,11S,11aR)-4,11-dihydroxy-9a,11a-dimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid|Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O|InChiKey: OEKUSRBIIZNLHZ-DJDNIQJZSA-N|InChi: InChI=1S/C24H38O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-14,16-20,22,26-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (245.97 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Male Goto-Kakizaki (GK) rats rats are subjected to Ileal transposition (IT) surgery. In the metabolomics analysis, compared with Sham-IT rats, 3-Oxocholic acid of IT rats is increased.|Products are for research use only. Not for human use.|

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Isopropyl ferulate, isolated from Rhizoma et Radix Notopterygii (Qianghuo), is used in the reduction of pharmaceuticals, preparation of antifungal agents, cosmetics and as antioxidant agent and so forth.|Product information|CAS Number: 59831-94-6|Molecular Weight: 236.26|Formula: C13H16O4|Chemical Name: propan-2-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate|Smiles: COC1=CC(/C=C/C(=O)OC(C)C)=CC=C1O|InChiKey: KBTWMQRNUHIETA-FNORWQNLSA-N|InChi: InChI=1S/C13H16O4/c1-9(2)17-13(15)7-5-10-4-6-11(14)12(8-10)16-3/h4-9,14H,1-3H3/b7-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Ingenol-5,20-acetonide is an intermediate from ingenol for synthesis of ingenoids; improved stability compared to ingenol.|Product information|CAS Number: 77573-43-4|Molecular Weight: 388.50|Formula: C23H32O5|Chemical Name: (1S,4S,6R,13S,14R,16R,18R)-4,5-dihydroxy-3,8,8,15,15,18-hexamethyl-7,9-dioxapentacyclo[11.{{Orexin 2 Receptor Agonist} site|{Orexin 2 Receptor Agonist} Orexin Receptor (OX Receptor)|{Orexin 2 Receptor Agonist} Purity & Documentation|{Orexin 2 Receptor Agonist} In Vivo|{Orexin 2 Receptor Agonist} custom synthesis|{Orexin 2 Receptor Agonist} Cancer} 5.PMID:32940134 1.0¹,⁵.0⁶,¹¹.0¹⁴,¹⁶]nonadeca-2,11-dien-19-one|Smiles: CC1=C[C@@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C5COC(C)(C)O[C@H]5C2(O)[C@H]1O)C3=O)C4(C)C|InChiKey: ONMDPPVVEFWDOD-VMUSEIHCSA-N|InChi: InChI=1S/C23H32O5/c1-11-9-22-12(2)7-15-16(20(15,3)4)14(18(22)25)8-13-10-27-21(5,6)28-19(13)23(22,26)17(11)24/h8-9,12,14-17,19,24,26H,7,10H2,1-6H3/t12-,14+,15-,16+,17+,19-,22+,23?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.|Product information|CAS Number: 118-42-3|Molecular Weight: 335.87|Formula: C18H26ClN3O|Chemical Name: 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol|Smiles: CCN(CCO)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C21|InChiKey: XXSMGPRMXLTPCZ-UHFFFAOYSA-N|InChi: InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mephenytoin} MedChemExpress|{Mephenytoin} Cytochrome P450|{Mephenytoin} NF-κB|{Mephenytoin} Technical Information|{Mephenytoin} Formula|{Mephenytoin} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Sotrovimab} web|{Sotrovimab} Anti-infection|{Sotrovimab} Protocol|{Sotrovimab} In stock|{Sotrovimab} supplier|{Sotrovimab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32809372 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).{{Glatiramer} web|{Glatiramer} Biological Activity|{Glatiramer} Formula|{Glatiramer} custom synthesis|{Glatiramer} Autophagy} |Product information|CAS Number: 874302-76-8|Molecular Weight: 352.PMID:31536190 39|Formula: C14H12N2O5S2|Chemical Name: 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate|Smiles: [O-][N+](=O)C1C=CC(=CC=1)OC(=O)OCCSSC1=CC=CC=N1|InChiKey: JHDROZPIXZYTMZ-UHFFFAOYSA-N|InChi: InChI=1S/C14H12N2O5S2/c17-14(21-12-6-4-11(5-7-12)16(18)19)20-9-10-22-23-13-3-1-2-8-15-13/h1-8H,9-10H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (283.78 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Spartalizumab} medchemexpress|{Spartalizumab} Immunology/Inflammation|{Spartalizumab} Biological Activity|{Spartalizumab} Description|{Spartalizumab} supplier|{Spartalizumab} Epigenetic Reader Domain} Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).PMID:32727246 |Product information|CAS Number: 1043426-13-6|Molecular Weight: 190.20|Formula: C6H14N4O3|Chemical Name: O-{2-[2-(2-azidoethoxy)ethoxy]ethyl}hydroxylamine|Smiles: [N-]=[N+]=NCCOCCOCCON|InChiKey: GCURLNTZWQFVMK-UHFFFAOYSA-N|InChi: InChI=1S/C6H14N4O3/c7-10-9-1-2-11-3-4-12-5-6-13-8/h1-6,8H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|

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Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 2100306-77-0|Molecular Weight: 313.39|Formula: C16H27NO5|Chemical Name: 2-(4,7,13,16-tetraoxa-10-azanonadeca-1,18-diyn-10-yl)ethan-1-ol|Smiles: C#CCOCCOCCN(CCO)CCOCCOCC#C|InChiKey: CFAWPKGCJLYIOW-UHFFFAOYSA-N|InChi: InChI=1S/C16H27NO5/c1-3-9-19-13-15-21-11-6-17(5-8-18)7-12-22-16-14-20-10-4-2/h1-2,18H,5-16H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Abietic acid} site|{Abietic acid} Anti-infection|{Abietic acid} Purity & Documentation|{Abietic acid} In Vitro|{Abietic acid} custom synthesis|{Abietic acid} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Varenicline} web|{Varenicline} Neuronal Signaling|{Varenicline} Protocol|{Varenicline} Description|{Varenicline} custom synthesis|{Varenicline} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31869128 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma.PMID:32967527 |Product information|CAS Number: 148471-91-4|Molecular Weight: 612.72|Formula: C35H40N4O6|Chemical Name: 3-[20-(2-carboxyethyl)-14-(1-hydroxyethyl)-9-(1-methoxyethyl)-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1,3(24),4,6,8,10,12,14,16,18(21),19-undecaen-4-yl]propanoic acid|Smiles: CC(O)C1C2=CC3NC(C=C4N=C(C=C5N=C(C=C(N2)C=1C)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C)=C(C(C)OC)C=3C|InChiKey: NDYWLKUTUDKOAS-OYYVZGGRSA-N|InChi: InChI=1S/C35H40N4O6/c1-16-22(8-10-32(41)42)28-15-29-23(9-11-33(43)44)17(2)25(37-29)13-31-35(21(6)45-7)19(4)27(39-31)14-30-34(20(5)40)18(3)26(38-30)12-24(16)36-28/h12-15,20-21,38-40H,8-11H2,1-7H3,(H,41,42)(H,43,44)/b24-12-,25-13-,26-12-,27-14-,28-15-,29-15-,30-14-,31-13-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). HMME-PDT can induce cell deaththrough both necrosis and apoptosis in HeLa cells. ROS, such as singlet oxygen and hydroxyl radical, generated in HeLa cells play a decisive role in HMME-PDT-induced cell death.|Products are for research use only. Not for human use.|

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Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.|Product information|CAS Number: 1698878-14-6|Molecular Weight: 419.49|Formula: C20H25N3O5S|Chemical Name: 2-hydroxy-2-methyl-N-{2-[2-(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}propane-1-sulfonamide|Smiles: CC(C)(O)CS(=O)(=O)NC1=CC2CCN(CC=2C=C1)C(=O)COC1C=NC=CC=1|InChiKey: QHHSCLARESIWBH-UHFFFAOYSA-N|InChi: InChI=1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (595.{{Nomegestrol} MedChemExpress|{Nomegestrol} Vitamin D Related/Nuclear Receptor|{Nomegestrol} Purity & Documentation|{Nomegestrol} Data Sheet|{Nomegestrol} manufacturer|{Nomegestrol} Autophagy} 96 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|To assess its selectivity, specificity, and effects on cellular NAD+ levels, LSN3154567 is characterized in various biochemical and cellular assays.{{Amiloride hydrochloride dihydrate} MedChemExpress|{Amiloride hydrochloride dihydrate} Inhibitor|{Amiloride hydrochloride dihydrate} TGF-beta/Smad|{Amiloride hydrochloride dihydrate} Protocol|{Amiloride hydrochloride dihydrate} In Vitro|{Amiloride hydrochloride dihydrate} supplier} LSN3154567 inhibits purified NAMPT with an IC50 of 3.1 nM. When tested against a panel of human kinases (>100; CEREP Kinase panel), it does not exhibit any significant activity (i.e.: IC50≥1 μM) against the kinases tested except CSF1R (IC50≈0.84 μM). LSN3154567 exhibits a broad spectrum of anticancer activity. To assess its anticancer activity, LSN3154567 is tested against a number of different types of cancer cell lines cultured in the absence or presence of nicotinic acid (NA) (10 μM).PMID:31916914 LSN3154567 exhibits a potent antiproliferative activity against many cell lines in the absence of NA.|In Vivo:|Nampt-IN-1 (LSN3154567) exhibits good physical chemical properties that allow oral dosing. When dosed orally with 2 mg/kg in mice, it has an exposure of 195 nM*hour in the plasma with a peak concentration of 57 nM (at 0.25 hour) and an oral bioavailability of 39%. When dosed intravenously with 2 mg/kg, it has a hepatic clearance of 158.73 mL/min/kg and a volume of distribution at 7.1 L/kg. The half-life of terminal elimination is estimated to be 2.76 hours. LSN3154567 exhibits a dose-dependent inhibition of NAD+ formation with estimated TED50 value of 2.0 mg/kg. To assess whether LSN3154567 causes retinopathy, rats are treated with LSN3154567 at 20, 40, and 80 mg/kg for 4 days. No apparent retinopathy is observed. The hematological toxicities are observed. When LSN3154567 is dosed at 20, 40, and 80 mg/kg, the plasma exposures obtained are 8,974, 18,061, and 38,327 M*h, respectively. Thus, LSN3154567 exhibits exposure multiples of respective 3-, 7-, and 14-fold over the exposure (2,701 M*h) required for robust efficacy (≈103%) without NA coadministration. Dogs are treated with LSN3154567 at 1 and 2.5 mg/kg. At these dose levels, the retinal toxicity is observed. Degeneration of the outer nuclear layer occurred in all four animals, but is less pronounced in the animals treated with 1 mg/kg. At the 1 and 2.5 mg/kg dose levels, the plasma exposures are determined to be 1,483 and 2,468 nM*h, respectively.|Products are for research use only. Not for human use.|

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Ms-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Abatacept} site|{Abatacept} CTLA-4|{Abatacept} Purity & Documentation|{Abatacept} In stock|{Abatacept} supplier|{Abatacept} Epigenetics} |Product information|CAS Number: 2097604-01-6|Molecular Weight: 576.PMID:32589561 70|Formula: C24H48O13S|Chemical Name: tert-butyl 1-(methanesulfonyloxy)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate|Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOS(C)(=O)=O|InChiKey: ARFPSYCSFDJABG-UHFFFAOYSA-N|InChi: InChI=1S/C24H48O13S/c1-24(2,3)37-23(25)5-6-28-7-8-29-9-10-30-11-12-31-13-14-32-15-16-33-17-18-34-19-20-35-21-22-36-38(4,26)27/h5-22H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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1-Eicosanol is a natural compound with antioxidant activity isolated from Hypericum carinatum.|Product information|CAS Number: 629-96-9|Molecular Weight: 298.{{α-MSH} site|{α-MSH} Melanocortin Receptor|{α-MSH} NF-κB|{α-MSH} Biological Activity|{α-MSH} In stock|{α-MSH} supplier} 55|Formula: C20H42O|Chemical Name: icosan-1-ol|Smiles: CCCCCCCCCCCCCCCCCCCCO|InChiKey: BTFJIXJJCSYFAL-UHFFFAOYSA-N|InChi: InChI=1S/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H,2-20H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32061246 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Fmoc-8-amino-3, 6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).{{Mephenytoin} MedChemExpress|{Mephenytoin} Metabolic Enzyme/Protease|{Mephenytoin} TGF-beta/Smad|{Mephenytoin} Technical Information|{Mephenytoin} Description|{Mephenytoin} manufacturer} Fmoc-8-amino-3, 6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Nourseothricin} site|{Nourseothricin} Inhibitor|{Nourseothricin} NF-κB|{Nourseothricin} Technical Information|{Nourseothricin} In stock|{Nourseothricin} manufacturer} |Product information|CAS Number: 166108-71-0|Molecular Weight: 385.41|Formula: C21H23NO6|Synonym:|Fmoc-NH-PEG2-CH2COOH|Chemical Name: 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid|Smiles: OC(=O)COCCOCCNC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21|InChiKey: XQPYRJIMPDBGRW-UHFFFAOYSA-N|InChi: InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32463711 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.Products are for research use only. Not for human use.|

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Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study.|Product information|CAS Number: 154709-18-9|Molecular Weight: 494.59|Formula: C33H26N4O|Chemical Name: {2′-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1′-biphenyl]-4-yl}methanol|Smiles: OCC1C=CC(=CC=1)C1=CC=CC=C1C1=NN=NN1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1|InChiKey: QTMWXNFBOZZDCQ-UHFFFAOYSA-N|InChi: InChI=1S/C33H26N4O/c38-24-25-20-22-26(23-21-25)30-18-10-11-19-31(30)32-34-35-36-37(32)33(27-12-4-1-5-13-27,28-14-6-2-7-15-28)29-16-8-3-9-17-29/h1-23,38H,24H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Abacavir} medchemexpress|{Abacavir} Anti-infection|{Abacavir} Biological Activity|{Abacavir} In Vitro|{Abacavir} supplier|{Abacavir} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Simvastatin} site|{Simvastatin} Mitophagy|{Simvastatin} Protocol|{Simvastatin} Formula|{Simvastatin} supplier|{Simvastatin} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32338564 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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CDK9-IN-10 is a potent CDK9 inhibitor.{{Brassicasterol} web|{Brassicasterol} PI3K/Akt/mTOR|{Brassicasterol} Activator|{Brassicasterol} Purity & Documentation|{Brassicasterol} References|{Brassicasterol} manufacturer} CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811).PMID:33319597 |Product information|CAS Number: 3542-63-0|Molecular Weight: 360.36|Formula: C22H16O5|Chemical Name: 7-(benzyloxy)-5, 8-dihydroxy-2-phenyl-4H-chromen-4-one|Smiles: OC1=C2OC(=CC(=O)C2=C(O)C=C1OCC1C=CC=CC=1)C1C=CC=CC=1|InChiKey: OQHAZMRRNANBMN-UHFFFAOYSA-N|InChi: InChI=1S/C22H16O5/c23-16-11-18(15-9-5-2-6-10-15)27-22-20(16)17(24)12-19(21(22)25)26-13-14-7-3-1-4-8-14/h1-12,24-25H,13H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.Products are for research use only. Not for human use.|

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Cyclo(Tyr-Leu) is a cyclic dipeptide.|Product information|CAS Number: 82863-65-8|Molecular Weight: 276.{{Caffeic acid phenethyl ester} MedChemExpress|{Caffeic acid phenethyl ester} Apoptosis|{Caffeic acid phenethyl ester} Protocol|{Caffeic acid phenethyl ester} Formula|{Caffeic acid phenethyl ester} custom synthesis|{Caffeic acid phenethyl ester} Epigenetic Reader Domain} 33|Formula: C15H20N2O3|Chemical Name: 3-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)piperazine-2,5-dione|Smiles: CC(C)CC1NC(=O)C(CC2=CC=C(O)C=C2)NC1=O|InChiKey: GENSLUDVKWKQMX-UHFFFAOYSA-N|InChi: InChI=1S/C15H20N2O3/c1-9(2)7-12-14(19)17-13(15(20)16-12)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8H2,1-2H3,(H,16,20)(H,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lycopene} site|{Lycopene} Reactive Oxygen Species|{Lycopene} Protocol|{Lycopene} In Vitro|{Lycopene} supplier|{Lycopene} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32750794 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Iristectorin B is an isoflavone from Iris tectorum, has anti-cancer activities in breast cancer.|Product information|CAS Number: 94396-09-5|Molecular Weight: 492.43|Formula: C23H24O12|Chemical Name: 5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one|Smiles: COC1=CC(=CC=C1O)C1=COC2=CC(OC3OC(CO)C(O)C(O)C3O)=C(OC)C(O)=C2C1=O|InChiKey: XVNKSNSGLVWSFS-UHFFFAOYSA-N|InChi: InChI=1S/C23H24O12/c1-31-12-5-9(3-4-11(12)25)10-8-33-13-6-14(22(32-2)19(28)16(13)17(10)26)34-23-21(30)20(29)18(27)15(7-24)35-23/h3-6,8,15,18,20-21,23-25,27-30H,7H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively.|Product information|CAS Number: 20958-17-2|Molecular Weight: 276.29|Formula: C18H12O3|Chemical Name: 4,8-dimethyl-7H,11H-phenanthro[3,2-b]furan-7,11-dione|Smiles: CC1=CC=CC2=C3C(=CC=C12)C(=O)C1=C(OC=C1C)C3=O|InChiKey: XYKZSUXWBGUGQV-UHFFFAOYSA-N|InChi: InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)18-14(16(13)19)10(2)8-21-18/h3-8H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator.{{Lomustine} MedChemExpress|{Lomustine} Autophagy|{Lomustine} Purity & Documentation|{Lomustine} In stock|{Lomustine} supplier|{Lomustine} Epigenetic Reader Domain} Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.|Product information|CAS Number: 183200-12-6|Molecular Weight: 1458.66|Formula: C58H87N15O21S4|Chemical Name: (1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-19-[(2S)-butan-2-yl]-22-(2-carboxyethyl)-25-[(2S,3R)-3-hydroxy-2-(2-{[(2S)-pyrrolidin-2-yl]formamido}acetamido)butanamido]-32-[(1R)-1-hydroxyethyl]-10-[(4-hydroxyphenyl)methyl]-4,7,13-trimethyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.PMID:32356935 13.13]dotetracontane-38-carboxylic acid|Smiles: CC[C@H](C)[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSSC[C@@H]2NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC3C=CC(O)=CC=3)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(O)=O)NC1=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1)[C@@H](C)O|InChiKey: XPNQMTAYRNMRRD-RDJGHUJSSA-N|InChi: InChI=1S/C58H87N15O21S4/c1-8-25(2)43-56(91)69-36-21-97-98-24-39(58(93)94)65-40(77)19-61-55(90)44(29(6)74)73-54(89)38(68-48(83)27(4)62-46(81)26(3)63-51(86)35(18-31-11-13-32(76)14-12-31)67-47(82)28(5)64-52(36)87)23-96-95-22-37(53(88)66-34(50(85)72-43)15-16-42(79)80)70-57(92)45(30(7)75)71-41(78)20-60-49(84)33-10-9-17-59-33/h11-14,25-30,33-39,43-45,59,74-76H,8-10,15-24H2,1-7H3,(H,60,84)(H,61,90)(H,62,81)(H,63,86)(H,64,87)(H,65,77)(H,66,88)(H,67,82)(H,68,83)(H,69,91)(H,70,92)(H,71,78)(H,72,85)(H,73,89)(H,79,80)(H,93,94)/t25-,26-,27-,28-,29+,30+,33-,34-,35-,36-,37-,38-,39-,43-,44-,45-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 1802908-04-8|Molecular Weight: 389.41|Formula: C17H23N7O4|Chemical Name: 3-[4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)phenyl]-6-methyl-1,2,4,5-tetrazine|Smiles: CC1N=NC(=NN=1)C1C=CC(=CC=1)OCCOCCOCCOCCN=[N+]=[N-]|InChiKey: AHJFUODPROPZLF-UHFFFAOYSA-N|InChi: InChI=1S/C17H23N7O4/c1-14-20-22-17(23-21-14)15-2-4-16(5-3-15)28-13-12-27-11-10-26-9-8-25-7-6-19-24-18/h2-5H,6-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Beclamide is a drug that possesses anticonvulsant activity. It is no longer used. Beclamide is possibly metabolized to 3-chloropropanoic acid in vivo, which binds to the GHB receptor. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.|Product information|CAS Number: 501-68-8|Molecular Weight: 197.66|Formula: C10H12ClNO|Chemical Name: N-Benzyl-3-chloropropionamide|Smiles: O=C(CCCl)NCC1C=CC=CC=1|InChiKey: JPYQFYIEOUVJDU-UHFFFAOYSA-N|InChi: InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 40 mg/mL(202.36 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Marine Movsisyan, et al. Chemistry. 2018 Aug 9;24(45):11779-11784.Products are for research use only. Not for human use.|

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Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp FO-2942. Amidepsine A is an inhibitor of dylglycerol acyltransferase (DGAT). Dylglycerol acyltransferase (DGAT) has been involved in catalyzing the formation of triglycerides from diacylglycerol and Acyl-CoA. The reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. There are two isozymes of DGAT have been identified: DGAT1 and DGAT2. DGAT-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance . DGAT2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities . FO-2942 inhibited DGAT activity with an IC50 of 10.2 μM in rat liver microsomes. FO-2942 inhibited triacylglycerol formation in Raji cells with the IC50 value of 15.5 μM .|Product information|CAS Number: 79786-34-8|Molecular Weight: 496.46|Formula: C26H24O10|Chemical Name: 4-[4-(2,4-dimethoxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoyloxy]-2-hydroxy-6-methylbenzoic acid|Smiles: CC1C=C(C=C(OC)C=1C(=O)OC1C=C(C)C(C(=O)OC2C=C(C)C(=C(O)C=2)C(O)=O)=C(O)C=1)OC|InChiKey: KODVVMZOLYYCMV-UHFFFAOYSA-N|InChi: InChI=1S/C26H24O10/c1-12-7-16(9-18(27)21(12)24(29)30)35-25(31)22-13(2)8-17(10-19(22)28)36-26(32)23-14(3)6-15(33-4)11-20(23)34-5/h6-11,27-28H,1-5H3,(H,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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IC50: 53 nM Cathepsin G (EC 3.4.PMID:24293312 21.20, chymotrypsin-like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 ± 12 (N = 10) and 63 ± 14 nM (N = 5), respectively. Another attribute of Cathepsin G Inhibitor I relates to its selectivity vs other serine proteases. It weakly inhibits chymotrypsin (Ki = 1.5 ± 0.2 μM), and poorly inhibits (Product information|CAS Number: 429676-93-7|Molecular Weight: 620.63|Formula: C36H33N2O6P|Chemical Name: (2-{3-[(1-benzoylpiperidin-4-yl)(methyl)carbamoyl]naphthalen-2-yl}-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid|Smiles: CN(C1CCN(CC1)C(=O)C1C=CC=CC=1)C(=O)C1=CC2=CC=CC=C2C=C1C(=O)C(C1=CC=CC2=CC=CC=C21)P(O)(O)=O|InChiKey: GNOZQRKYZJSIPZ-UHFFFAOYSA-N|InChi: InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Celastramycin A is an antibiotic that inhibits the growth of bacteria and mycobacteria and is also a potent innate immune suppressor . Celastramycin A is a benzoyl pyrrole-type compound isolated from endophytic bacteria Streptomyces MaB-QuH-8 living in plants of the Celastraceae family. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria . Celastramycin A inhibited the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC) as low as 0.05 μg/ml . In the ex vivo Drosophila culture system, Celastramycin A showed a potent immunosuppressive effect with IC50 value of 0.008 μg/mL. In human umbilical vein endothelial cells (HUVECs), Celastramycin A potently inhibited the production of IL-8 with IC50 value of 0.06 μg/mL. So Celastramycin A could be used as a lead compound for novel immunosuppressive agents .|Product information|CAS Number: 491600-94-3|Molecular Weight: 390.69|Formula: C17H18Cl3NO3|Chemical Name: 4-chloro-2-(4,5-dichloro-1H-pyrrole-2-carbonyl)-6-hexylbenzene-1,3-diol|Smiles: CCCCCCC1C=C(Cl)C(O)=C(C(=O)C2=CC(Cl)=C(Cl)N2)C=1O|InChiKey: VPAMZQVPJOAFJG-UHFFFAOYSA-N|InChi: InChI=1S/C17H18Cl3NO3/c1-2-3-4-5-6-9-7-10(18)15(23)13(14(9)22)16(24)12-8-11(19)17(20)21-12/h7-8,21-23H,2-6H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 880759-65-9|Molecular Weight: 723.69|Formula: C38H44Cl2N4O6|Chemical Name: (1S,5R,13S,14Z,17S)-14-{2-[(1S,5R,13S,14E,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-ylidene]hydrazin-1-ylidene}-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-triene-10,17-diol dihydrochloride|Smiles: Cl.{{Omidenepag} site|{Omidenepag} Prostaglandin Receptor|{Omidenepag} Biological Activity|{Omidenepag} Formula|{Omidenepag} supplier|{Omidenepag} Epigenetics} Cl.{{Sulindac} MedChemExpress|{Sulindac} PD-1/PD-L1|{Sulindac} Biological Activity|{Sulindac} Formula|{Sulindac} custom synthesis|{Sulindac} Epigenetic Reader Domain} C=CCN1CC[C@@]23[C@@H]4OC5C2=C(C[C@@H]1[C@]3(O)CC/C/4=N/N=C1\CC[C@@]2(O)[C@H]3CC4C=CC(O)=C6O[C@H]\1[C@]2(CCN3CC=C)C=46)C=CC=5O|InChiKey: VIAIHLLKDJKEKM-KZFJLXDDSA-N|InChi: InChI=1S/C38H42N4O6.PMID:28630660 2ClH/c1-3-15-41-17-13-35-29-21-5-7-25(43)31(29)47-33(35)23(9-11-37(35,45)27(41)19-21)39-40-24-10-12-38(46)28-20-22-6-8-26(44)32-30(22)36(38,34(24)48-32)14-18-42(28)16-4-2;;/h3-8,27-28,33-34,43-46H,1-2,9-20H2;2*1H/b39-23-,40-24+;;/t27-,28-,33-,34-,35+,36+,37-,38-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 439861-56-0|Molecular Weight: 351.44|Formula: C21H25N3O2|Chemical Name: N-[4-methyl-9-(propan-2-yl)-9H-carbazol-3-yl]morpholine-4-carboxamide|Smiles: CC1C(=CC=C2C=1C1=CC=CC=C1N2C(C)C)NC(=O)N1CCOCC1|InChiKey: ZNFMHLDBJPAFEQ-UHFFFAOYSA-N|InChi: InChI=1S/C21H25N3O2/c1-14(2)24-18-7-5-4-6-16(18)20-15(3)17(8-9-19(20)24)22-21(25)23-10-12-26-13-11-23/h4-9,14H,10-13H2,1-3H3,(H,22,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sacubitril} site|{Sacubitril} Metabolic Enzyme/Protease|{Sacubitril} Protocol|{Sacubitril} In Vitro|{Sacubitril} supplier|{Sacubitril} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23695992 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 280570-45-8|Molecular Weight: 371.39|Formula: C21H17N5O2|Chemical Name: 3-(2-methoxyphenyl)-1-[2-(pyridin-3-yl)quinazolin-4-yl]urea|Smiles: COC1=CC=CC=C1NC(=O)NC1=NC(=NC2=CC=CC=C21)C1C=NC=CC=1|InChiKey: YRAFEJSZTVWUMD-UHFFFAOYSA-N|InChi: InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Deferasirox} medchemexpress|{Deferasirox} Anti-infection|{Deferasirox} Protocol|{Deferasirox} Formula|{Deferasirox} supplier|{Deferasirox} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24179643 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC.|Product information|CAS Number: 1677668-27-7|Molecular Weight: 433.84|Formula: C23H16ClN3O4|Chemical Name: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid|Smiles: OC(=O)C1=CC=C(C=C1O)C1N=C(C(=O)C2C(Cl)=CC=CC=2C2CC2)N2C=CC=NC2=1|InChiKey: GIYKJPISDNWSJD-UHFFFAOYSA-N|InChi: InChI=1S/C23H16ClN3O4/c24-16-4-1-3-14(12-5-6-12)18(16)20(29)22-26-19(21-25-9-2-10-27(21)22)13-7-8-15(23(30)31)17(28)11-13/h1-4,7-12,28H,5-6H2,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (11.{{MARK-IN-2} web|{MARK-IN-2} AMPK|{MARK-IN-2} Activator|{MARK-IN-2} Protocol|{MARK-IN-2} Formula|{MARK-IN-2} manufacturer} 52 mM; Need ultrasonic).{{Vitamin D2} web|{Vitamin D2} Metabolic Enzyme/Protease|{Vitamin D2} Biological Activity|{Vitamin D2} Data Sheet|{Vitamin D2} manufacturer|{Vitamin D2} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25040798 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) .|Products are for research use only. Not for human use.|

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Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.|Product information|CAS Number: 6601-62-3|Molecular Weight: 314.29|Formula: C17H14O6|Chemical Name: 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one|Smiles: COC1C=C2OC(=CC(=O)C2=C(O)C=1OC)C1C=CC(O)=CC=1|InChiKey: ZIIAJIWLQUVGHB-UHFFFAOYSA-N|InChi: InChI=1S/C17H14O6/c1-21-14-8-13-15(16(20)17(14)22-2)11(19)7-12(23-13)9-3-5-10(18)6-4-9/h3-8,18,20H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 22.73 mg/mL (72.{{Demeclocycline} MedChemExpress|{Demeclocycline} Antibiotic|{Demeclocycline} Protocol|{Demeclocycline} In stock|{Demeclocycline} manufacturer|{Demeclocycline} Epigenetic Reader Domain} 32 mM; Need ultrasonic).{{Ibudilast} medchemexpress|{Ibudilast} Phosphodiesterase (PDE)|{Ibudilast} Protocol|{Ibudilast} In Vitro|{Ibudilast} supplier|{Ibudilast} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24507727 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds.|Products are for research use only. Not for human use.|

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Emtricitabine S-oxide (Emtricitabine sulfoxide) is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.|Product information|CAS Number: 152128-77-3|Molecular Weight: 263.25|Formula: C8H10FN3O4S|Chemical Name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-3-oxo-1,3λ⁴-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one|Smiles: NC1=NC(=O)N(C=C1F)[C@@H]1CS(=O)[C@H](CO)O1|InChiKey: DMOMZPWPIDCLMB-YGFFCSEESA-N|InChi: InChI=1S/C8H10FN3O4S/c9-4-1-12(8(14)11-7(4)10)5-3-17(15)6(2-13)16-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+,17?/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35670838 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).|Products are for research use only. Not for human use.|

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Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines.|Product information|CAS Number: 81189-92-6|Molecular Weight: 446.58|Formula: C26H38O6|Chemical Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-(acetyloxy)-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate|Smiles: CC(=O)O[C@H]1CC(=O)O[C@@H](C1)CC[C@@H]1[C@H]2[C@H](C[C@@H](C)C=C2C=C[C@@H]1C)OC(=O)[C@@H](C)CC|InChiKey: OYNSFDWALRRTFU-QQVNEASTSA-N|InChi: InChI=1S/C26H38O6/c1-6-16(3)26(29)32-23-12-15(2)11-19-8-7-17(4)22(25(19)23)10-9-20-13-21(30-18(5)27)14-24(28)31-20/h7-8,11,15-17,20-23,25H,6,9-10,12-14H2,1-5H3/t15-,16-,17-,20+,21+,22-,23-,25-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (559.{{VAL-083} site|{VAL-083} Cell Cycle/DNA Damage|{VAL-083} Protocol|{VAL-083} Data Sheet|{VAL-083} custom synthesis|{VAL-083} Epigenetics} 81 mM).PMID:28630660 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.|Product information|CAS Number: 1888378-12-8|Molecular Weight: 446.25|Formula: C13H13BrFN7O3S|Chemical Name: (Z)-N-(3-bromo-4-fluorophenyl)-4-({2-[(cyanoimino)(methyl)oxo-λ⁶-sulfanyl]ethyl}amino)-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide|Smiles: CS(=O)(CCNC1=NON=C1/C(/NC1C=C(Br)C(F)=CC=1)=N/O)=NC#N|InChiKey: GGHPYZYCOWLIBW-UHFFFAOYSA-N|InChi: InChI=1S/C13H13BrFN7O3S/c1-26(24,18-7-16)5-4-17-12-11(21-25-22-12)13(20-23)19-8-2-3-10(15)9(14)6-8/h2-3,6,23H,4-5H2,1H3,(H,17,22)(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Eflornithine} site|{Eflornithine} Anti-infection|{Eflornithine} Purity & Documentation|{Eflornithine} Purity|{Eflornithine} manufacturer|{Eflornithine} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Epcoritamab} web|{Epcoritamab} CD3|{Epcoritamab} Protocol|{Epcoritamab} In Vivo|{Epcoritamab} supplier|{Epcoritamab} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23600560 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor.|Product information|Molecular Weight: 888.93|Formula: C42H55F3N8O10|Chemical Name: (2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid; trifluoroacetic acid|Smiles: CC(C)[C@H](N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O.OC(=O)C(F)(F)F|InChiKey: FCDOCNHFFAOXJR-BPXNUQSUSA-N|InChi: InChI=1S/C40H54N8O8.C2HF3O2/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25;3-2(4,5)1(6)7/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56);(H,6,7)/t24-,29-,30-,31-,32-,33-,34-;/m0.PMID:25818744 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 50 mg/mL (56.25 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances.|Products are for research use only. Not for human use.|

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GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.|Product information|CAS Number: 141636-65-9|Molecular Weight: 904.06|Formula: C49H61N9O8|Chemical Name: (2S)-2-{[(2S)-1-[(2R)-1-[(2S)-2-[(2R)-3-(1H-indol-3-yl)-2-[(2S)-2-[(2S)-2-(phenylformamido)propanamido]propanamido]propanamido]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}hexanamide|Smiles: CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)C1C=CC=CC=1)C(N)=O|InChiKey: CWEISCOCKRHHOU-UJYVDGJVSA-N|InChi: InChI=1S/C49H61N9O8/c1-4-5-21-37(42(50)59)54-47(64)40-23-14-25-57(40)49(66)41-24-15-26-58(41)48(65)39(27-32-16-8-6-9-17-32)56-46(63)38(28-34-29-51-36-22-13-12-20-35(34)36)55-44(61)31(3)52-43(60)30(2)53-45(62)33-18-10-7-11-19-33/h6-13,16-20,22,29-31,37-41,51H,4-5,14-15,21,23-28H2,1-3H3,(H2,50,59)(H,52,60)(H,53,62)(H,54,64)(H,55,61)(H,56,63)/t30-,31-,37-,38+,39-,40-,41+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Celecoxib} site|{Celecoxib} COX|{Celecoxib} Technical Information|{Celecoxib} Description|{Celecoxib} manufacturer|{Celecoxib} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Primidone} medchemexpress|{Primidone} Sodium Channel|{Primidone} Protocol|{Primidone} Data Sheet|{Primidone} supplier|{Primidone} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23558135 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM).|Products are for research use only. Not for human use.|

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Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).|Product information|CAS Number: 359625-79-9|Molecular Weight: 366.43|Formula: C22H23FN2O2|Chemical Name: 2-({1-[2-(4-fluorophenyl)-2-oxoethyl]piperidin-4-yl}methyl)-2,3-dihydro-1H-isoindol-1-one|Smiles: O=C1C2C=CC=CC=2CN1CC1CCN(CC(=O)C2C=CC(F)=CC=2)CC1|InChiKey: RNRYULFRLCBRQS-UHFFFAOYSA-N|InChi: InChI=1S/C22H23FN2O2/c23-19-7-5-17(6-8-19)21(26)15-24-11-9-16(10-12-24)13-25-14-18-3-1-2-4-20(18)22(25)27/h1-8,16H,9-15H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.{{DBCO-Biotin} medchemexpress|{DBCO-Biotin} PROTAC Linkers|{DBCO-Biotin} Immunology/Inflammation|{DBCO-Biotin} Protocol|{DBCO-Biotin} In Vitro|{DBCO-Biotin} supplier} 33 mg/mL (90.PMID:23614016 96 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Roluperidone (CYR-101) also shows binding affinity for α1-adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways, as well as in calcium neuronal modulation.|Products are for research use only. Not for human use.|

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Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.|Product information|CAS Number: 301847-37-0|Molecular Weight: 402.53|Formula: C19H22N4O2S2|Chemical Name: 5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylsulfanyl)thieno[2,3-d]pyrimidine-6-carboxamide|Smiles: CSC1=NC(=C2C(N)=C(SC2=N1)C(=O)NC(C)(C)C)C1C=C(C=CC=1)OC|InChiKey: DVSFSADBOJYPGF-UHFFFAOYSA-N|InChi: InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (248.{{Masofaniten} web|{Masofaniten} Androgen Receptor|{Masofaniten} NF-κB|{Masofaniten} Technical Information|{Masofaniten} In stock|{Masofaniten} custom synthesis} 43 mM; Need ultrasonic).{{Epalrestat} medchemexpress|{Epalrestat} Metabolic Enzyme/Protease|{Epalrestat} Protocol|{Epalrestat} In stock|{Epalrestat} manufacturer|{Epalrestat} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23443926 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR).|Products are for research use only. Not for human use.|