Herbimycin A

Herbimycin A__Hsp90 inhibitor HBX 19818

Product Name	Herbimycin A
Description	Hsp90 inhibitor
Purity	>98%
CAS No.	70563-58-5
Molecular Formula	C30H42N2O10, C30H42N2O9
Molecular Weight	574.3, 575.3

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Source	Synthetic
Appearance	Yellow Solid
SMILES	Cemail protected1CC@@H(C@@H(email protected(/C=C(/C@@H(email protected(/C=CC=C(C(=O)NC2=CC(=O)C=C(C@@H1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC
InChI	InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(
InChIKey	MCAHMSDENAOJFZ-BVXDHVRPSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	Herbimycin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-116)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1912835

Alternative Names	(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo16.3.1docosa-1(21),8,12,14,18-pentaen-10-yl carbamate
Research Areas	Cancer, Heat Shock
PubChem ID	6436247
Scientific Background	Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
References	1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370. 2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661. 3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537. 4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.