Name :
RAF1 (Y340D/Y341D) (Human) Recombinant Protein
Biological Activity :
Human RAF1 (NM_002880.2, 306 a.a. – 648 a.a.) Y340D and Y341D mutant partial protein expressed in Sf9 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins
Tag :
Result of activity analysis
Protein Accession No. :
NM_002880.2
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=5894
Amino Acid Sequence :
Molecular Weight :
38.472
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing
Host :
insect
Interspecies Antigen Sequence :
Preparation Method :
Insect cell (Sf9) expression system
Purification :
GST affinity chromatography
Quality Control Testing :
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer :
In 50 mM Hepes, 100 mM NaCl, pH 7.5 (5 mM DTT, 20% glycerol)
Applications :
Functional Study， SDS-PAGE，
Gene Name :
RAF1
Gene Alias :
CRAF, NS5, Raf-1, c-Raf
Gene Description :
v-Raf-1 murine leukemia viral oncogene homolog 1
Gene Summary :
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
Other Designations :
Oncogene RAF1|raf proto-oncogene serine/threonine protein kinase
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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