Mouse CD27/TNFRSF7 Protein 2097

Additional Information:
accession P41272|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundCD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a costimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.|molecular weightThe protein has a predicted MW of 19.40 kDa. Due to glycosylation, the protein migrates to 38-48 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse CD27/TNFRSF7 Protein 2097proteinSize and concentration100, 500g and liquidFormLiquidStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped with dry ice.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceCD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.Protein namesCD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)Gene namesCD27,CD27 Tnfrsf7Mass10090DaFunctionReceptor specifically expressed at the surface of T cells which binds and is activated by its ligand CD70/CD27L expressed by B cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells.Subellular locationCell membrane ; Single-pass type I membrane protein .TissuesIn thymus and spleen, but not in non-lymphoid tissues.StructureHomodimer. Interacts with SIVA1; may play a role in apoptosis through association with SIVA1. Interacts with TRAF2.Post-translational modificationPhosphorylated.; N-glycosylated.; O-glycosylated with core 1 or possibly core 8 glycans.Target Relevance information above includes information from UniProt accession: P41272The UniProt Consortium|