Product Name :
PNU112455A hydrochloride
Synonym :
Chemical Name :
CAS NO.:
21886-12-4
Molecular formula :
C10H12ClN5O2S
Molecular Weight:
301.75 g/mol
Classification :
MedChemExpress Products > Research Chemicals > PNU112455A hydrochloride
Description:
PNU112455A hydrochloride is a small-molecule growth factor that is a potent inhibitor of the CDK4/6 enzyme. PNU112455A hydrochloride binds to and dephosphorylates CDK4/6, which inhibits the phosphorylation of Rb by cyclin E and prevents the transition from G1 to S phase in cells. PNU112455A hydrochloride has been shown to inhibit growth in cancer cells such as MDA-MB-231 breast cancer cells, epidermal growth factor receptor (EGFR), and miapaca-2 cells. It appears to have a cell-specific apoptotic effect.
Purity :
>98%
Specifications :
10 mM * 1 mL
Price.:
94
Price unit :
$
Inventory :
In stock
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