GF109203X

GF109203X__PKC kinase inhibitor GW2580

Product Name GF109203X
Description

PKC kinase inhibitor

Purity >98% (TLC)
CAS No. 133052-90-1
Molecular Formula C25H24N4O2
Molecular Weight 412.5
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)
Source Synthetic
Appearance Red solid
SMILES C4=C(C3=C(C1=CNHC2=CC=CC=C12)C(=O)NC3=O)C5=C(N4CCCN(C)C)C=CC=C5
InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChIKey QMGUOJYZJKLOLH-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 4), H302
Carcinogenicity (Category 2), H351

Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H302 Harmful if swallowed.
H351 Suspected of causing cancer.

Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

Cite This Product GF109203X (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-447)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19125643

Alternative Names 2-1-(3-Dimethylaminopropyl)indol-3-yl-3-(indol-3-yl) maleimide, 3-(N-Dimethylaminopropyl-3-indolyl)-4-(3-indolyl)maleimide, 3-1-3-(Dimethylamino)propyl1H-indol-3-yl-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I
Research Areas Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 2396
Scientific Background GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.
References 1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781.
2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.
3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.
4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.