GF109203X__PKC kinase inhibitor GW2580
Product Name
GF109203X
Description
PKC kinase inhibitor
Purity
>98% (TLC)
CAS No.
133052-90-1
Molecular Formula
C25H24N4O2
Molecular Weight
412.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)
Source
Synthetic
Appearance
Red solid
SMILES
C4=C(C3=C(C1=CNHC2=CC=CC=C12)C(=O)NC3=O)C5=C(N4CCCN(C)C)C=CC=C5
InChI
InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChIKey
QMGUOJYZJKLOLH-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4), H302
Carcinogenicity (Category 2), H351
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
H351 Suspected of causing cancer.
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
GF109203X (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-447)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19125643
Alternative Names
2-1-(3-Dimethylaminopropyl)indol-3-yl-3-(indol-3-yl) maleimide, 3-(N-Dimethylaminopropyl-3-indolyl)-4-(3-indolyl)maleimide, 3-1-3-(Dimethylamino)propyl1H-indol-3-yl-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
2396
Scientific Background
GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.
References
1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781.
2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.
3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.
4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.
PKC kinase inhibitor
Acute toxicity, Oral (Category 4), H302
Carcinogenicity (Category 2), H351
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
H351 Suspected of causing cancer.
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.
3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.
4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.