Tankyrase-tankyrase.com

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Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle.|Product information|CAS Number: 29767-20-2|Molecular Weight: 656.65|Formula: C32H32O13S|Chemical Name: (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one|Smiles: COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@H](O[C@H]3[C@H](O)[C@H]2O)C2=CC=CS2)C2=CC3OCOC=3C=C21|InChiKey: NRUKOCRGYNPUPR-QBPJDGROSA-N|InChi: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mometasone furoate} site|{Mometasone furoate} Vitamin D Related/Nuclear Receptor|{Mometasone furoate} Purity & Documentation|{Mometasone furoate} In stock|{Mometasone furoate} custom synthesis|{Mometasone furoate} Autophagy} |Shelf Life: ≥360 days if stored properly.{{SQ109} medchemexpress|{SQ109} Parasite|{SQ109} Epigenetics|{SQ109} Purity & Documentation|{SQ109} Formula|{SQ109} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:36014399 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Clemizole, also known as AL 20, P 48, or Reactrol, is a potent inhibitor of transient receptor potential channel TRPC5.PMID:23659187 Clemizole efficiently blocks TRPC5 currents and Ca(2+) entry in the low micromolar range (IC50 = 1.0-1.3 µM). Clemizole blocks TRPC5 currents irrespectively of the mode of activation. Based on fluorometric [Ca(2+)]i measurements, clemizole exhibits a sixfold selectivity for TRPC5 over TRPC4β (IC50 = 6.4 µM). Clemizole was not only effective in blocking heterologously expressed TRPC5 homomers but also TRPC1:TRPC5 heteromers as well as native TRPC5-like currents in the U-87 glioblastoma cell line.|Product information|CAS Number: 1163-36-6|Molecular Weight: 362.30|Formula: C19H21Cl2N3|Chemical Name: 1-[(4-chlorophenyl)methyl]-2-[(pyrrolidin-1-yl)methyl]-1H-1,3-benzodiazole hydrochloride|Smiles: Cl.ClC1=CC=C(CN2C3=CC=CC=C3N=C2CN2CCCC2)C=C1|InChiKey: DNFMJYXRIMLMBZ-UHFFFAOYSA-N|InChi: InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC50 of 0.{{Omburtamab} web|{Omburtamab} Immunology/Inflammation|{Omburtamab} Biological Activity|{Omburtamab} In Vitro|{Omburtamab} manufacturer|{Omburtamab} Epigenetic Reader Domain} 9 nM.PMID:27217159 It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. GSK2656157 inhibits PERK activity in cells with an IC50 in the range of 10-30 nM as shown by inhibition of stress-induced PERK autophosphorylation, eIF2α substrate phosphorylation, together with corresponding decreases in ATF4 and CHOP proteins in multiple cell lines. Oral administration of GSK2656157 to mice shows a dose- and time-dependent pharmacodynamic response in pancreas as measured by PERK auto-phosphorylation.|Product information|CAS Number: 1337532-29-2|Molecular Weight: 416.45|Formula: C23H21FN6O|Chemical Name: 1-(5-{4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-(6-methylpyridin-2-yl)ethan-1-one|Smiles: CN1C=C(C2=C1N=CN=C2N)C1=CC=C2C(CCN2C(=O)CC2=CC=CC(C)=N2)=C1F|InChiKey: PRWSIEBRGXYXAJ-UHFFFAOYSA-N|InChi: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.|Product information|CAS Number: 6054-98-4|Molecular Weight: 325.23|Formula: C14H10N2NaO6|Chemical Name: 5-[2-(3-carboxy-4-hydroxyphenyl)diazen-1-yl]-2-hydroxybenzoic acid sodium|Smiles: [Na].{{Escitalopram} MedChemExpress|{Escitalopram} Neuronal Signaling|{Escitalopram} Purity & Documentation|{Escitalopram} Formula|{Escitalopram} supplier|{Escitalopram} Epigenetic Reader Domain} OC1C=CC(=CC=1C(O)=O)N=NC1C=C(C(O)=CC=1)C(O)=O |^1:0||InChiKey: DOGQIVPYEFSMNI-GEEYTBSJSA-N|InChi: InChI=1S/C14H10N2O6.{{Inotuzumab} MedChemExpress|{Inotuzumab} ADC Antibody|{Inotuzumab} Protocol|{Inotuzumab} Formula|{Inotuzumab} manufacturer|{Inotuzumab} Autophagy} Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;/h1-6,17-18H,(H,19,20)(H,21,22);/b16-15+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23910527 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Amorolfine HCl is a 14-alpha demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. In also increases release for prostaglandin D2 metabolites and inhibits production of thymic stromal lymphopoietin in dermatitis models.|Product information|CAS Number: 78613-38-4|Molecular Weight: 353.97|Formula: C21H36ClNO|Chemical Name: (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine hydrochloride|Smiles: Cl.CCC(C)(C)C1=CC=C(CC(C)CN2C[C@H](C)O[C@H](C)C2)C=C1|InChiKey: XZKWIPVTHGWDCF-KUZYQSSXSA-N|InChi: InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis.|Product information|CAS Number: 3811-73-2|Molecular Weight: 149.15|Formula: C5H4NNaOS|Chemical Name: sodium 2-sulfanylidene-1,2-dihydropyridin-1-olate|Smiles: [Na+].[O-]N1C=CC=CC1=S|InChiKey: XNRNJIIJLOFJEK-UHFFFAOYSA-N|InChi: InChI=1S/C5H4NOS.Na/c7-6-4-2-1-3-5(6)8;/h1-4H;/q-1;+1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi.PMID:23659187 Neocnidilide also has larvicidal activity against D. melanogaster with a LC50 value of 9.9 μmol/mL.|Product information|CAS Number: 4567-33-3|Molecular Weight: 194.27|Formula: C12H18O2|Chemical Name: (3S,3aR)-3-butyl-1,3,3a,4,5,6-hexahydro-2-benzofuran-1-one|Smiles: CCCC[C@@H]1OC(=O)C2=CCCC[C@H]21|InChiKey: UPJFTVFLSIQQAV-KOLCDFICSA-N|InChi: InChI=1S/C12H18O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h7,9,11H,2-6,8H2,1H3/t9-,11+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Resibufogenin, a component of huachansu, has been shown to exhibit the anti-proliferative effect against cancer cells, and this may be attributed to the degradation of cyclin D1 caused by the activation of GSK-3β.IC50 Value:Target:In vitro: The effects of Resibufogenin on the outward delayed rectifier potassium current (IK) and outward transient potassium current (IA) in rat hippocampal neurons was investigated, and it inhibited both IK and IA, at 1 μM concentration RBG could alter some channel kinetics and gating properties of IK, such as steady-state activation and inactivation curves, open probability and time constants .In vivo: Resibufogenin prevented evidence of oxidative stress in “preeclamptic” rats .|Product information|CAS Number: 465-39-4|Molecular Weight: 384.{{D-Glucose-13C6,d7} medchemexpress|{D-Glucose-13C6,d7} Bacterial|{D-Glucose-13C6,d7} NF-κB|{D-Glucose-13C6,d7} Biological Activity|{D-Glucose-13C6,d7} In Vitro|{D-Glucose-13C6,d7} custom synthesis} 51|Formula: C24H32O4|Chemical Name: 5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.PMID:23075432 8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadecan-6-yl]-2H-pyran-2-one|Smiles: C[C@]12CC[C@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@H](C[C@H]3O[C@]213)C1C=CC(=O)OC=1|InChiKey: ATLJNLYIJOCWJE-CWMZOUAVSA-N|InChi: InChI=1S/C24H32O4/c1-22-9-7-16(25)11-15(22)4-5-18-17(22)8-10-23(2)19(12-20-24(18,23)28-20)14-3-6-21(26)27-13-14/h3,6,13,15-20,25H,4-5,7-12H2,1-2H3/t15-,16+,17+,18-,19-,20-,22+,23-,24-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (260.07 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1).|Product information|CAS Number: 2651200-35-8|Molecular Weight: 454.36|Formula: C18H15F5N8O|Chemical Name: N-((6, 7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-8-(trifluoromethyl)pyrazolo[1, 5-a][1, 3, 5]triazin-4-amine|Smiles: FC(F)(F)C1C=NN2C(NCC3NC4=C(C=CC(F)=C4F)N=3)=NC(=NC2=1)N1CCOCC1|InChiKey: XFZQHKMIWRKKCU-UHFFFAOYSA-N|InChi: InChI=1S/C18H15F5N8O/c19-10-1-2-11-14(13(10)20)27-12(26-11)8-24-16-29-17(30-3-5-32-6-4-30)28-15-9(18(21,22)23)7-25-31(15)16/h1-2,7H,3-6,8H2,(H,26,27)(H,24,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Neuromedin B} medchemexpress|{Neuromedin B} Endogenous Metabolite|{Neuromedin B} Technical Information|{Neuromedin B} Data Sheet|{Neuromedin B} custom synthesis|{Neuromedin B} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:34816786 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CDK12-IN-5 (Example 426) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=3.23 nM) and has no effect on CAL-120 cells. CDK12-IN-5 has antproliferative activity in MDA-MB-231 cells (IC50=4.19 nM) and CAL-120 cells (IC50=3.57 nM). CDK12-IN-5 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 32.|Products are for research use only. Not for human use.|

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cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors.|Product information|CAS Number: 618-27-9|Molecular Weight: 131.13|Formula: C5H9NO3|Chemical Name: (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid|Smiles: O[C@@H]1CN[C@@H](C1)C(O)=O|InChiKey: PMMYEEVYMWASQN-IMJSIDKUSA-N|InChi: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively.{{Stenoparib} web|{Stenoparib} Inhibitor|{Stenoparib} Epigenetics|{Stenoparib} Protocol|{Stenoparib} In stock|{Stenoparib} custom synthesis} Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia.PMID:23819239 |Product information|CAS Number: 1164469-60-6|Molecular Weight: 428.95|Formula: C24H29ClN2O3|Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride|Smiles: Cl.COC1=CC=CC=C1N1CCN(CC(O)COC2=CC=CC3=CC=CC=C32)CC1|InChiKey: VQAAEWMEVIOHTJ-UHFFFAOYSA-N|InChi: InChI=1S/C24H28N2O3.ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;/h2-12,20,27H,13-18H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC. Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.|In Vivo:|Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.|Products are for research use only. Not for human use.|

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Benzyl-PEG11-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|Molecular Weight: 670.{{Veratridine} web|{Veratridine} Membrane Transporter/Ion Channel|{Veratridine} Biological Activity|{Veratridine} Formula|{Veratridine} supplier|{Veratridine} Autophagy} 81|Formula: C30H54O14S|Chemical Name: 1-phenyl-2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32-undecaoxatetratriacontan-34-yl methanesulfonate|Smiles: CS(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC1C=CC=CC=1|InChiKey: HSFQECWASGNADY-UHFFFAOYSA-N|InChi: InChI=1S/C30H54O14S/c1-45(31,32)44-28-27-42-24-23-40-20-19-38-16-15-36-12-11-34-8-7-33-9-10-35-13-14-37-17-18-39-21-22-41-25-26-43-29-30-5-3-2-4-6-30/h2-6H,7-29H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} medchemexpress|{Rucaparib} Cell Cycle/DNA Damage|{Rucaparib} Protocol|{Rucaparib} In Vivo|{Rucaparib} supplier|{Rucaparib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24455443 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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[D-Asn5]-Oxytocin possesses very low specific oxytocic and vasodepressor activities. By cumulative dose-response studies for oxytocic activity, [D-Asn5]-Oxytocin has similar intrinsic activity to oxytocin.|Product information|CAS Number: 5754-53-0|Molecular Weight: 1007.19|Formula: C43H66N12O12S2|Chemical Name: (2S)-2-{[(2S)-1-[(4R, 7R, 10S, 13S, 16S, 19R)-19-amino-13-[(2S)-butan-2-yl]-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6, 9, 12, 15, 18-pentaoxo-1, 2-dithia-5, 8, 11, 14, 17-pentaazacycloicosane-4-carbonyl]pyrrolidin-2-yl]formamido}-N-(carbamoylmethyl)-4-methylpentanamide|Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O|InChiKey: XNOPRXBHLZRZKH-KKBHKYMDSA-N|InChi: InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29+,30-,31-,35-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ibotenic acid} MedChemExpress|{Ibotenic acid} iGluR|{Ibotenic acid} Purity & Documentation|{Ibotenic acid} Description|{Ibotenic acid} supplier|{Ibotenic acid} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Ciprofloxacin} medchemexpress|{Ciprofloxacin} Topoisomerase|{Ciprofloxacin} Protocol|{Ciprofloxacin} Data Sheet|{Ciprofloxacin} custom synthesis|{Ciprofloxacin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23376608 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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6-Oxohexanoic acid is a non-cleavable modified MMAF-C5-COOH linker and can be used in the synthesis of modified MMAF-C5-COOH, a drug-linker conjugate for ADC.|Product information|CAS Number: 928-81-4|Molecular Weight: 130.14|Formula: C6H10O3|Chemical Name: 6-oxohexanoic acid|Smiles: OC(=O)CCCCC=O|InChiKey: PNPPVRALIYXJBW-UHFFFAOYSA-N|InChi: InChI=1S/C6H10O3/c7-5-3-1-2-4-6(8)9/h5H,1-4H2,(H,8,9)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rivastigmine} web|{Rivastigmine} Cholinesterase (ChE)|{Rivastigmine} Purity & Documentation|{Rivastigmine} In Vivo|{Rivastigmine} manufacturer|{Rivastigmine} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23892407 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.|Products are for research use only. Not for human use.|

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Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle.{{Doxazosin} web|{Doxazosin} Neuronal Signaling|{Doxazosin} Purity & Documentation|{Doxazosin} In Vitro|{Doxazosin} supplier|{Doxazosin} Cancer} This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.PMID:24576999 |Product information|CAS Number: 143-67-9|Molecular Weight: 909.05|Formula: C46H60N4O13S|Synonym:|Vincaleukoblastine sulfate salt|Chemical Name: methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(1R,13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0⁴,¹².0⁵,¹⁰]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate; sulfuric acid|Smiles: CN1[C@@H]2[C@]3(CCN4CC=C[C@](CC)([C@@H]34)[C@@H](OC(C)=O)[C@]2(O)C(=O)OC)C2=CC(=C(C=C12)OC)[C@]1(C[C@@H]2C[C@](O)(C[N@@](C2)CCC2=C1NC1=CC=CC=C21)CC)C(=O)OC.OS(O)(=O)=O|InChiKey: KDQAABAKXDWYSZ-PNYVAJAMSA-N|InChi: InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity. CDKI R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation.{{Eflornithine} web|{Eflornithine} Parasite|{Eflornithine} Purity & Documentation|{Eflornithine} Description|{Eflornithine} supplier|{Eflornithine} Autophagy} CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells.|Product information|CAS Number: 741713-40-6|Molecular Weight: 441.45|Formula: C18H21F2N5O4S|Chemical Name: (4-amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2, 3-difluoro-6-methoxyphenyl)methanone|Smiles: COC1=CC=C(F)C(F)=C1C(=O)C1=CN=C(NC2CCN(CC2)S(C)(=O)=O)N=C1N|InChiKey: JRNJNYBQQYBCLE-UHFFFAOYSA-N|InChi: InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 60 mg/mL(135.91 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|R547 identified as a diaminopyrimidine compound, which is a potent and selective ATP-competitive CDK inhibitor.PMID:23543429 R547 effectively inhibits CDK1/cyclinB, CDK2/cyclinE, and CDK4/cyclinD1(Ki=1-3nM) and is inactive(Ki>5, 000nM) against a panel of >120 unrelated kinases. R547 effectively inhibits the proliferation of tumor cell lines independent of multidrug resistant status, histologic type, retinoblastoma protein, or p53 status, with IC50s R547 possessing both 5-and 6-fluoro substitution culminated in an Inhibitor with low, single-digit nanomolar potency against the CDKs(Ki=0.001, 0.003, and 0.001 μM for CDK1, CDK2, and CDK4, respectively) and excellent cellular potency (IC50=0.08 μM, HCT116 cell line).|In Vivo:|R547 administered with oral and i.v. dosing in multiple established human tumor significantly inhibits tumor activity(P R547 inhibits tumor growth up to 95% in the HCT116 human colorectal tumor xenograft model in nude mice . R547 causes significant TGI in all of the models tested when dosed orally and i.v. at or below the maximum tolerated dose. R547 inhibits phosphorylation of retinoblastoma protein in tumors at the efficacious exposures in tumor xenograft models, providing a pharmacodynamic biomarker for clinical use. R547 reported here suggests that this is a promising molecule for evaluation in the treatment of solid tumors.|References:|Berkofsky-Fessler W, et al. Mol Cancer Ther, 2009, 8(9), 2517-2525.Chu XJ, et al. J Med Chem, 2006, 49(22), 6549-6560.Rodriguez A , et al. Mol Cancer Ther, 2006, 5(11), 2644-2658.Products are for research use only. Not for human use.|

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Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. It is used for both standard and rapid sequence induction (RSI).{{Mifanertinib dimaleate} MedChemExpress|{Mifanertinib dimaleate} Protein Tyrosine Kinase/RTK|{Mifanertinib dimaleate} Protocol|{Mifanertinib dimaleate} Description|{Mifanertinib dimaleate} custom synthesis|{Mifanertinib dimaleate} Epigenetics} Rocuronium bromide competitively binds to the nicotinic receptor at the motor end plate, and antagonizes acetylcholine binding.|Product information|CAS Number: 119302-91-9|Molecular Weight: 609.68|Formula: C32H53BrN2O4|Synonym:|Zemuron|Rocuronium (Bromide)|Esmeron|UNII-I65MW4OFHZ|Esmerone|ORG 9426|ORG-9426|Related CAS Number:|143558-00-3 (Rocuronium cation)|Chemical Name: [(2S, 3S, 5S, 8R, 9S, 10S, 13S, 14S, 16S, 17R)-3-hydroxy-10, 13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;bromide|Smiles: [Br-].CC12CCC3C(CCC4CC(O)C(CC43C)N3CCOCC3)C1CC(C2OC(C)=O)[N+]1(CC=C)CCCC1|InChiKey: OYTJKRAYGYRUJK-UHFFFAOYSA-M|InChi: InChI=1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 122 mg/mL(200.1 mM). Water: 122 mg/mL(200.1 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site.{{9-cis-Retinoic acid} site|{9-cis-Retinoic acid} RAR/RXR|{9-cis-Retinoic acid} Epigenetics|{9-cis-Retinoic acid} Biological Activity|{9-cis-Retinoic acid} In Vitro|{9-cis-Retinoic acid} custom synthesis} Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively.PMID:22664133 |In Vivo:|Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats.|References:|Auer U, et al. Vet Ophthalmol,?011, 14(4), 244-247.Anzenbacherova E, et al. J Pharmacol Sci,?015, 127(2), 190-195.Zan U, et al. Cytotechnology,?011, 63(3), 239-245.Products are for research use only. Not for human use.|

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TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM.|Product information|CAS Number: 936091-56-4|Molecular Weight: 510.65|Formula: C26H34N6O3S|Chemical Name: N-tert-Butyl-3-[[5-methyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide|Smiles: CC1=CN=C(NC2=CC(CN3CCOCC3)=CC=C2)N=C1NC1=CC(=CC=C1)S(=O)(=O)NC(C)(C)C|InChiKey: OOSKXASFJFSOBK-UHFFFAOYSA-N|InChi: InChI=1S/C26H34N6O3S/c1-19-17-27-25(29-21-8-5-7-20(15-21)18-32-11-13-35-14-12-32)30-24(19)28-22-9-6-10-23(16-22)36(33,34)31-26(2,3)4/h5-10,15-17,31H,11-14,18H2,1-4H3,(H2,27,28,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C) DMSO: 10 mg/mL(19.{{Nimorazole} MedChemExpress|{Nimorazole} Antibiotic|{Nimorazole} Protocol|{Nimorazole} Purity|{Nimorazole} custom synthesis|{Nimorazole} Autophagy} 58 mM).{{Bortezomib} site|{Bortezomib} NF-κB|{Bortezomib} Protocol|{Bortezomib} In Vitro|{Bortezomib} manufacturer|{Bortezomib} Autophagy} Water: ˂1 mg/mL.PMID:23439434 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Kirill Gorshkov, et al. Transl Oncol. 2019 Mar;12(3):441-452.Products are for research use only. Not for human use.|

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CID 1375606 is an agonist of GPR27 SREB1 that induces coupling of the receptor to arrestin 2|Product information|CAS Number: 313493-80-0|Molecular Weight: 385.{{Clobetasol propionate} web|{Clobetasol propionate} Cytochrome P450|{Clobetasol propionate} NF-κB|{Clobetasol propionate} Biological Activity|{Clobetasol propionate} In Vivo|{Clobetasol propionate} custom synthesis} 24|Formula: C20H14Cl2N2O2|Chemical Name: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide|Smiles: O=C(C1=CC=C(Cl)C=C1Cl)N(C1C=CC=CC=1)C(=O)NC1C=CC=CC=1|InChiKey: ZQAVKJQEPSJXHB-UHFFFAOYSA-N|InChi: InChI=1S/C20H14Cl2N2O2/c21-14-11-12-17(18(22)13-14)19(25)24(16-9-5-2-6-10-16)20(26)23-15-7-3-1-4-8-15/h1-13H,(H,23,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 77 mg/mL(199.PMID:24268253 87 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CID 1375606 is a GPR27-specific surrogate agonist. GPR27 is characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion[1].|References:|Dupuis N, et al. Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment. Mol Pharmacol. 2017 Jun;91(6):595-608.Products are for research use only. Not for human use.|

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DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the ‘DFG-out’ conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.|Product information|CAS Number: 1449685-96-4|Molecular Weight: 552.59|Formula: C30H31F3N4O3|Synonym:|DDR1-IN1|DDR1-IN-1|DDR1-IN 1|DDR1-IN1.|Chemical Name: 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide|Smiles: CC1=CC=C(C=C1OC1=CC2CC(=O)NC=2C=C1)NC(=O)C1=CC(=C(CN2CCN(CC2)CC)C=C1)C(F)(F)F|InChiKey: AOZPVMOOEJAZGK-UHFFFAOYSA-N|InChi: InChI=1S/C30H31F3N4O3/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 References:|Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol. 2014 Jun 26;426(13):2457-70. doi: 10.1016/j.jmb.2014.04.014. Epub 2014 Apr 23. PubMed PMID: 24768818; PubMed Central PMCID: PMC4058747.Products are for research use only. Not for human use.|

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Cariprazine, also known as RGH-188 and MP-214, is an antipsychotic drug received FDA approval on September 17, 2015. Cariprazine acts as a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder. Cariprazine is approved for schizophrenia and bipolar disorder. It has also been investigated as a potential adjunct in treatment-resistant major depressive disorder.|Product information|CAS Number: 839712-12-8|Molecular Weight: 427.41|Formula: C21H32Cl2N4O|Synonym:|RGH-188|MP-214|Cariprazine free base|RGH188|RGH 188|MP 214|MP214|Chemical Name: 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea|Smiles: CN(C)C(=O)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl|InChiKey: KPWSJANDNDDRMB-QAQDUYKDSA-N|InChi: InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Cariprazine stimulates inositol phosphate (IP) formation with a high potency (pEC50 8.5) with relatively low efficacy (Emax 30%). Cariprazine, a novel candidate antipsychotic, demonstrated approximately 10-fold higher affinity for human D3 versus human D2L and human D2S receptors (pKi 10.{{Celecoxib} web|{Celecoxib} COX|{Celecoxib} Biological Activity|{Celecoxib} Description|{Celecoxib} custom synthesis|{Celecoxib} Epigenetic Reader Domain} 07, 9.{{Cobicistat} site|{Cobicistat} Metabolic Enzyme/Protease|{Cobicistat} Purity & Documentation|{Cobicistat} References|{Cobicistat} manufacturer|{Cobicistat} Epigenetic Reader Domain} 16, and 9.PMID:23310954 31, respectively). Cariprazine displays high affinity at human serotonin (5-HT) type 2B receptors (pKi 9.24) with pure antagonism. Cariprazine has lower affinity at human and rat hippocampal 5-HT1A receptors (pKi 8.59 and 8.34, respectively) and demonstrates low intrinsic efficacy. Cariprazine displays low affinity at human 5-HT2A receptors (pKi 7.73). Moderate or low affinity for histamine H1 and 5-HT2C receptors (pKi 7.63 and 6.87, respectively) suggest Cariprazine’s reduced propensity for adverse events related to these receptors[2]. Cariprazine is over sixfold more potent (EC50=1.4 nM) than Aripiprazole (EC50=9.2 nM) in inhibiting isoproterenol-induced cAMP production in HEK-293 cells.|In Vivo:|Administration of Cariprazine (30 µg/kg) reduces the striatal uptake of both radioligands to the level of nonspecific binding compared with baseline PET measurements. Cariprazine has negligible effect on the time-activity curves in the cerebellum. At doses of 5.0 and 30 µg/kg, Cariprazine causes a dose-dependent dopamine D2/D3 receptor occupancy of ~45% and ~80% for both antagonist [11C] raclopride and agonist radioligand [11C]MNPA. Receptor occupancy of dopamine D2/D3 receptors calculated using the transient equilibrium and the MRTM2 methods ranged from 5% at the lowest dose (1.0 µg/kg) to 94% at the highest dose (300 µg/kg). The effects of 5 doses of Cariprazine (ranging from 0.005 to 0.15 mg/kg) are examined on EPM behavior of wild-type mice. Whereas lower doses of Cariprazine (0.005 to 0.02 mg/kg) do not alter the time spent in open arms, the two higher doses (0.08 and 0.15 mg/kg) lead to a significant decline of this measure (ANOVA, (F(5, 52)=4.20; p=0.0032)). Moreover, the two higher doses of Cariprazine also lead to a significant decrease in the total number of arm entries (F(5, 52)=7.21; p=0.0001)) but this decrease in the total number of arm entries is largely accounted for by a significant decrease in the number of closed arm entries (F(5, 52)=11.75; p=0.0001)). The two highest doses of Cariprazine (0.08 and 0.15 mg/kg) have significant effects on locomotor activity, but doses ranging from 0.005 to 0.02 mg/kg do not affect anxiety-like behavior or locomotor activity in the EPM test. A significant (PReferences:|Rolin D, Whelan J, Montano CB. Is it depression or is it bipolar depression? J Am Assoc Nurse Pract. 2020 Oct;32(10):703-713. doi: 10.1097/JXX.0000000000000499. PMID: 33017361.Edinoff A, Ruoff MT, Ghaffar YT, Rezayev A, Jani D, Kaye AM, Cornett EM, Kaye AD, Viswanath O, Urits I. Cariprazine to Treat Schizophrenia and Bipolar Disorder in Adults. Psychopharmacol Bull. 2020 Sep 14;50(4):83-117. PMID: 33012874; PMCID: PMC7511151.Dieci M, Trama A, Mansi G. Resolution of Citalopram Sexual Adverse Effects With Low Dose of Cariprazine: A Case Report. Clin Neuropharmacol. 2020 Sep/Oct;43(5):164-165. doi: 10.1097/WNF.0000000000000409. PMID: 32947429.Products are for research use only. Not for human use.|

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DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases.|Product information|CAS Number: 56687-67-3|Molecular Weight: 322.53|Formula: C21H38O2|Synonym:|DCPLA methyl ester|Chemical Name: DCPLA-ME|Smiles: CCCCCC1CC1CC1CC1CCCCCCCC(=O)OC|InChiKey: WSVAMWHCPDAWFM-UHFFFAOYSA-N|InChi: InChI=1S/C21H38O2/c1-3-4-8-11-17-14-19(17)16-20-15-18(20)12-9-6-5-7-10-13-21(22)23-2/h17-20H,3-16H2,1-2H3|Technical Data|Appearance: Solid Power.{{Ridaforolimus} site|{Ridaforolimus} Inhibitor|{Ridaforolimus} Activator|{Ridaforolimus} Protocol|{Ridaforolimus} References|{Ridaforolimus} supplier} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ciforadenant} medchemexpress|{Ciforadenant} GPCR/G Protein|{Ciforadenant} Immunology/Inflammation|{Ciforadenant} Protocol|{Ciforadenant} In Vitro|{Ciforadenant} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:24428212 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Thomas J. Nelson, et al. Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases. WO2015058191A1.Products are for research use only. Not for human use.|

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JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable.|Product information|CAS Number: 1802326-66-4|Molecular Weight: 316.78|Formula: C17H17ClN2O2|Synonym:|JNJ 63533054|JNJ63533054|JNJ-63533054|Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide|Smiles: C[C@H](NC(=O)CNC(=O)C1=CC(Cl)=CC=C1)C1C=CC=CC=1|InChiKey: MWDVCHRYCKXEBY-LBPRGKRZSA-N|InChi: InChI=1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Liu C, Bonaventure P, Lee G, Nepomuceno D, Kuei C, Wu J, Li Q, Joseph V, Sutton SW, Eckert W, Yao X, Yieh L, Dvorak C, Carruthers N, Coate H, Yun S, Dugovic C, Harrington A, Lovenberg TW. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25. doi: 10.1124/mol.115.100412. Epub 2015 Sep 8. PubMed PMID: 26349500.Products are for research use only. Not for human use.|

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GW501516 is a PPARδ receptor agonist.{{Omeprazole} medchemexpress|{Omeprazole} Autophagy|{Omeprazole} Protocol|{Omeprazole} In Vivo|{Omeprazole} manufacturer|{Omeprazole} Autophagy} Endurobol was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.PMID:24576999 |Product information|CAS Number: 317318-70-0|Molecular Weight: 453.50|Formula: C21H18F3NO3S2|Synonym:|Endurobol|GSK-516|GW-1516|GW501516|GW-501516|GW 501516|GW1516|GW 1516|GSK 516|GSK516|Chemical Name: {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid|Smiles: CC1=CC(=CC=C1OCC(O)=O)SCC1SC(=NC=1C)C1C=CC(=CC=1)C(F)(F)F|InChiKey: YDBLKRPLXZNVNB-UHFFFAOYSA-N|InChi: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|GW501516 is shown to be the most potent and selective PPARα agonists known with an EC50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.|In Vivo:|GW501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.|References:|Chen W, Gao R, Xie X, Zheng Z, Li H, Li S, Dong F, Wang L. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015 May 6;5:9884. doi: 10.1038/srep09884. PubMed PMID: 25943561; PubMed Central PMCID: PMC4421799.Magliano DC, Penna-de-Carvalho A, Vazquez-Carrera M, Mandarim-de-Lacerda CA, Aguila MB. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine. 2015 Nov;50(2):355-67. doi: 10.1007/s12020-015-0590-1. Epub 2015 Apr 9. PubMed PMID: 25854303.Wang X, Sng MK, Foo S, Chong HC, Lee WL, Tang MB, Ng KW, Luo B, Choong C, Wong MT, Tong BM, Chiba S, Loo SC, Zhu P, Tan NS. Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. J Control Release. 2015 Jan 10;197:138-47. doi: 10.1016/j.jconrel.2014.11.001. Epub 2014 Nov 7. PubMed PMID: 25449811.Products are for research use only. Not for human use.|

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CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells.{{Brassicasterol} site|{Brassicasterol} HSV|{Brassicasterol} TGF-beta/Smad|{Brassicasterol} Protocol|{Brassicasterol} In Vitro|{Brassicasterol} custom synthesis} CPI-455 mediated KDM5 inhibition, elevated global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.PMID:24914310 Pretreatment of cancer cells with a KDM5-specific inhibitor results in the ablation of a subpopulation of cancer cells that can serve as the founders for therapeutic relapse.|Product information|CAS Number: 1628208-23-0|Molecular Weight: 278.31|Formula: C16H14N4O|Chemical Name: 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile|Smiles: CC(C)C1C(=O)N2N=CC(C#N)=C2NC=1C1C=CC=CC=1|InChiKey: DHXKRMSKXLDZGY-UHFFFAOYSA-N|InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7,9-10,19H,1-2H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|KDM5-C70 was used at 1-10 µM in vitro and cellular assays.|References:|Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. (2016) Nat Chem Biol. 12(7):531-8.Products are for research use only. Not for human use.|Documents||

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VLX600 is a potent and selective mitochondrial OXPHOS inhibitor. It is preferentially active against quiescent cells in colon cancer 3-D microtissues (low micromole activity). The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.{{Eprenetapopt} medchemexpress|{Eprenetapopt} Activator|{Eprenetapopt} Epigenetics|{Eprenetapopt} Technical Information|{Eprenetapopt} References|{Eprenetapopt} supplier} It induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs.{{Isosorbide mononitrate} web|{Isosorbide mononitrate} Autophagy|{Isosorbide mononitrate} Purity & Documentation|{Isosorbide mononitrate} In Vitro|{Isosorbide mononitrate} manufacturer|{Isosorbide mononitrate} Cancer} It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.PMID:24324376 Right now it is in phase I clinical trials for patients with refractory advanced solid tumors.|Product information|CAS Number: 327031-55-0|Molecular Weight: 317.35|Formula: C17H15N7|Chemical Name: 2-[1-(2-{6-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl}hydrazin-1-ylidene)ethyl]pyridine|Smiles: CC(=NNC1N=C2NC3=C(C=CC=C3C)C2=NN=1)C1=CC=CC=N1|InChiKey: UQOSBPRTQFFUOA-SRZZPIQSSA-N|InChi: InChI=1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|VLX600 was used at 6 µM final concentration in various in vitro assays.|In Vivo:|VLX600 was dosed intravenously to mice at 16 mg/kg every third day for 16 days in xenografts models.|References:|Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. (2014) Nat Commun. 5:3295.Products are for research use only. Not for human use.|Documents||

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Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone.{{Terutroban} web|{Terutroban} GPCR/G Protein|{Terutroban} Purity & Documentation|{Terutroban} References|{Terutroban} custom synthesis|{Terutroban} Autophagy} Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].|Product information|CAS Number: 146062-46-6|Molecular Weight: 408.90|Formula: C19H21ClN2O4S|Smiles: Cl.CC(O)C1=CC=C(CCOC2C=CC(CC3SC(=O)NC3=O)=CC=2)N=C1|InChiKey: SBHOQYCDAHAMDW-UHFFFAOYSA-N|InChi: InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{ERK1/2 inhibitor 2} site|{ERK1/2 inhibitor 2} Apoptosis|{ERK1/2 inhibitor 2} Protocol|{ERK1/2 inhibitor 2} Formula|{ERK1/2 inhibitor 2} custom synthesis|{ERK1/2 inhibitor 2} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:28440459 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.Products are for research use only. Not for human use.|

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Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death.|Product information|CAS Number: 1402055-25-7|Molecular Weight: 409.82|Formula: C21H16ClN3O4|Chemical Name: ethyl 2-[(2-chlorophenyl)amino]-4-hydroxy-5-{[(3Z)-3H-pyrrolo[2,3-b]pyridin-3-ylidene]methyl}furan-3-carboxylate|Smiles: CCOC(=O)C1C(O)=C(/C=C2\C=NC3=NC=CC=C\23)OC=1NC1=CC=CC=C1Cl|InChiKey: MNEODYFHQBZJNQ-ZRDIBKRKSA-N|InChi: InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,25-26H,2H2,1H3/b12-10+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5.{{Zalcitabine} web|{Zalcitabine} Anti-infection|{Zalcitabine} NF-κB|{Zalcitabine} Biological Activity|{Zalcitabine} In Vitro|{Zalcitabine} custom synthesis} 2 mg/mL (12.PMID:34816786 69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.|Product information|CAS Number: 76958-99-1|Molecular Weight: 570.67|Formula: C28H35KO10|Chemical Name: potassium 4-{[(1R,2R,4aR,5R,8aS)-2-[(3-carboxypropanoyl)oxy]-1,4a-dimethyl-6-methylidene-5-[(E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl]-decahydronaphthalen-1-yl]methoxy}-4-oxobutanoate|Smiles: [K+].{{Clindamycin palmitate} site|{Clindamycin palmitate} Antibiotic|{Clindamycin palmitate} Technical Information|{Clindamycin palmitate} In stock|{Clindamycin palmitate} supplier|{Clindamycin palmitate} Epigenetics} C[C@@]12CC[C@@H](OC(=O)CCC(O)=O)[C@@](C)(COC(=O)CCC([O-])=O)[C@H]1CCC(=C)[C@H]2/C=C/C1=CCOC1=O|InChiKey: ASSFASHREXZFDB-IPPKWHAOSA-M|InChi: InChI=1S/C28H36O10.{{Citric acid} site|{Citric acid} Anti-infection|{Citric acid} Protocol|{Citric acid} In Vivo|{Citric acid} custom synthesis|{Citric acid} Epigenetic Reader Domain} K/c1-17-4-7-20-27(2,19(17)6-5-18-13-15-36-26(18)35)14-12-21(38-25(34)11-9-23(31)32)28(20,3)16-37-24(33)10-8-22(29)30;/h5-6,13,19-21H,1,4,7-12,14-16H2,2-3H3,(H,29,30)(H,31,32);/q;+1/p-1/b6-5+;/t19-,20+,21-,27+,28+;/m1.PMID:24633055 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (8.76 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Flufiprole is a nonsystemic phenylpyrazole insecticide targeting the GABA receptor used in the rice field. Flufiprole is excellent in controlling a wide range of pests.|Product information|CAS Number: 704886-18-0|Molecular Weight: 491.24|Formula: C16H10Cl2F6N4OS|Chemical Name: 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-trifluoromethanesulfinyl-1H-pyrazole-3-carbonitrile|Smiles: CC(=C)CNC1=C(C(C#N)=NN1C1C(Cl)=CC(=CC=1Cl)C(F)(F)F)S(=O)C(F)(F)F|InChiKey: HVQHXBNMBZJPLK-UHFFFAOYSA-N|InChi: InChI=1S/C16H10Cl2F6N4OS/c1-7(2)6-26-14-13(30(29)16(22,23)24)11(5-25)27-28(14)12-9(17)3-8(4-10(12)18)15(19,20)21/h3-4,26H,1,6H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pritelivir} MedChemExpress|{Pritelivir} HSV|{Pritelivir} Protocol|{Pritelivir} Data Sheet|{Pritelivir} manufacturer|{Pritelivir} Cancer} |Shelf Life: ≥12 months if stored properly.{{Ganciclovir} site|{Ganciclovir} Nucleoside Antimetabolite/Analog|{Ganciclovir} Protocol|{Ganciclovir} References|{Ganciclovir} custom synthesis|{Ganciclovir} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23892407 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Valemetostat tosylate (DS-3201 tosylate), a first-in-class EZH1/2 dual inhibitor, has the potential in the research of relapsed/refractory peripheral T-cell lymphoma.|Product information|CAS Number: 1809336-93-3|Molecular Weight: 660.22|Formula: C33H42ClN3O7S|Chemical Name: (2R)-7-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-[4-(dimethylamino)cyclohexyl]-2,4-dimethyl-2H-1,3-benzodioxole-5-carboxamide; 4-methylbenzene-1-sulfonic acid|Smiles: CC1C=CC(=CC=1)S(O)(=O)=O.PMID:25959043 CC1C=C(C)NC(=O)C=1CNC(=O)C1=CC(Cl)=C2O[C@@](C)(OC2=C1C)C1CCC(CC1)N(C)C|InChiKey: JSBKGJUYSLVFPF-RRKMXGHKSA-N|InChi: InChI=1S/C26H34ClN3O4.C7H8O3S/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6;1-6-2-4-7(5-3-6)11(8,9)10/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32);2-5H,1H3,(H,8,9,10)/t17?,18?,26-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (189.33 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Desmethyl cariprazine is an active metabolite of Cariprazine. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).|Product information|CAS Number: 839712-15-1|Molecular Weight: 413.38|Formula: C20H30Cl2N4O|Chemical Name: 1-(4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-3-methylurea|Smiles: CNC(=O)NC1CCC(CCN2CCN(CC2)C2=CC=CC(Cl)=C2Cl)CC1|InChiKey: WMQLLTKSISGWHQ-UHFFFAOYSA-N|InChi: InChI=1S/C20H30Cl2N4O/c1-23-20(27)24-16-7-5-15(6-8-16)9-10-25-11-13-26(14-12-25)18-4-2-3-17(21)19(18)22/h2-4,15-16H,5-14H2,1H3,(H2,23,24,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35116795 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Adynerin is a natural steroid found in the herbs of Nerium oleander.{{Olaratumab} web|{Olaratumab} Protein Tyrosine Kinase/RTK|{Olaratumab} Purity & Documentation|{Olaratumab} In Vivo|{Olaratumab} supplier|{Olaratumab} Cancer} |Product information|CAS Number: 35109-93-4|Molecular Weight: 516.{{Paclitaxel} web|{Paclitaxel} Microtubule/Tubulin|{Paclitaxel} Protocol|{Paclitaxel} Data Sheet|{Paclitaxel} custom synthesis|{Paclitaxel} Autophagy} 67|Formula: C30H44O7|Chemical Name: 4-[(1S,3R,6R,7R,10R,11S,14S,16R)-14-{[(2R,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-7,11-dimethyl-2-oxapentacyclo[8.PMID:23554582 8.0.0¹,³.0³,⁷.0¹¹,¹⁶]octadecan-6-yl]-2,5-dihydrofuran-2-one|Smiles: C[C@H]1O[C@H](C[C@@H](OC)[C@H]1O)O[C@@H]1C[C@H]2CC[C@@]34O[C@]53CC[C@H](C3COC(=O)C=3)[C@@]5(C)CC[C@@H]4[C@@]2(C)CC1|InChiKey: BYZQVAOKDQTHHP-QFUJVLJYSA-N|InChi: InChI=1S/C30H44O7/c1-17-26(32)22(33-4)15-25(35-17)36-20-6-9-27(2)19(14-20)5-11-29-23(27)8-10-28(3)21(7-12-30(28,29)37-29)18-13-24(31)34-16-18/h13,17,19-23,25-26,32H,5-12,14-16H2,1-4H3/t17-,19-,20+,21-,22-,23-,25+,26+,27+,28-,29+,30-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 1189713-08-3|Molecular Weight: 199.{{Triptolide} MedChemExpress|{Triptolide} Apoptosis|{Triptolide} Protocol|{Triptolide} Purity|{Triptolide} manufacturer|{Triptolide} Autophagy} 18|Formula: C7H8N4O3|Chemical Name: 1-(²H₃)methyl-7-methyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione|Smiles: [2H]C([2H])([2H])N1C(=O)NC2NC(=O)N(C)C=2C1=O|InChiKey: NOFNCLGCUJJPKU-BMSJAHLVSA-N|InChi: InChI=1S/C7H8N4O3/c1-10-3-4(8-6(10)13)9-7(14)11(2)5(3)12/h1-2H3,(H,8,13)(H,9,14)/i2D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24428212 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|