H89 Dihydrochloride__PKA inhibitor AM966
Product Name
H89 Dihydrochloride
Description
PKA inhibitor
Purity
99% (TLC)
CAS No.
127243-85-0
Molecular Formula
C20H22BrCl2N3O2S
Molecular Weight
519.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (25 mg/ml), methanol and 50% ethanol/water (20 mg/ml)
Source
Synthetic
Appearance
White to off-white solid
SMILES
C1=C(C2=C(C=C1)C=NC=C2)S(NCCNCC=CC3=CC=C(Br)C=C3)(=O)=O
InChI
InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
InChIKey
ZKZXNDJNWUTGDK-NSCUHMNNSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
H89 Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-452)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19127730
Alternative Names
N-2-(p-Bromocinnamylamino)ethyl-5-isoquinolinesulfonamide . 2HCl
Research Areas
Cell Signaling
PubChem ID
449241
Scientific Background
H89 Dihydrochloride is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It has also been shown to inhibit CaM kinase II, casein kinase I and MYLK, as well as, Rsk-2, MSK1, Akt1, PKC µ, Rock-2, p70 S6 kinase α. H89 Dihydrochloride can induce apoptosis. It is cell permeable.
References
1. Bouschet, T., (2003) J. Biol. Chem. 278(7): 4778–4785.
2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21.
3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105.
PKA inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21.
3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105.