Ionomycin

Ionomycin__Ca2+ ionophore MK-0975

Product Name	Ionomycin
Description	Ca2+ ionophore
Purity	>98%
CAS No.	56092-81-0
Molecular Formula	C41H70O9
Molecular Weight	709.01

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 10 mM in ethanol and to 10 mM in DMSO
Source	Synthetic
Appearance	Colorless Solid
SMILES	Cemail protected(CCC(=O)O)Cemail protected(C)Cemail protected(C)C(=O)/C=C(/email protected(C)Cemail protected(C)C/C=C/C@@H(C)email protected(C@@H(C)email protected(CC@@H1CCC@@(O1)(C)email protected2CCC@@(O2)(C)C@@H(C)O)O)O)O
InChI	InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23
InChIKey	PGHMRUGBZOYCAA-OJFQOPKISA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
Cite This Product	Ionomycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-228)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19133137

Alternative Names	(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-(1R)-1-hydroxyethyl-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid, Ionomycin calcium salt
Research Areas	Cancer, Apoptosis
PubChem ID	6434517
Scientific Background	Ionomycin is a calcium ionophore used in research to raise the intracellular level of calcium and as a tool to understand calcium transport across biological membranes. It is also used to stimulare the intracellular production of the cytokines interferon, perforin, IL-2 and IL-4. It is more specific than A23187.
References	1. Holmes A.G. Watt M.J., Carey A.L. And Febbraio M.A. (2004) Metabolism. 53(11): 1492-1495. 2. Abramov A.Y., Duchen M.R. (2003) Cell Calcium. 33(2): 101-112.