Itraconazole__Cytochrome P450 inhibitor NVP-BKM121
Product Name
Itraconazole
Description
Cytochrome P450 inhibitor
Purity
>98%
CAS No.
84625-61-6
Molecular Formula
C35H38Cl2N8O4
Molecular Weight
705.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in chloroform (50 mg/ml)
Source
Synthetic
SMILES
CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCemail protected5COC@@(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,1
InChIKey
VHVPQPYKVGDNFY-ZPGVKDDISA-N
Safety Phrases
Classification:
D1B Toxic Material Causing Immediate and Serious Toxic Effects – Toxic by ingestion
D2A Very Toxic Material Causing Other Toxic Effects – Teratogen
D2B Toxic Material Causing Other Toxic Effects – Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
Itraconazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-543)
Alternative Names
Itraconazole, 84625-61-6, Sporanox, ITRAZOLE, Itraconazolum, Oriconazole, R51211, Sporanox, 4-4-4-4-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Research Areas
Cancer, Angiogenesis, Autophagy, Cardiovascular System, Growth Factors
PubChem ID
3793
Scientific Background
Itraconazole is an triazol antifungal agent. It inhibits P-450 dependent enzymes, which results in the inhibition of ergosterol synthesis.
Cytochrome P450 inhibitor
D1B Toxic Material Causing Immediate and Serious Toxic Effects – Toxic by ingestion
D2A Very Toxic Material Causing Other Toxic Effects – Teratogen
D2B Toxic Material Causing Other Toxic Effects – Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.