Mifepristone (RU486)

Mifepristone (RU486)__Glucocorticoid antagonist Tebipenem

Product Name	Mifepristone (RU486)
Description	Glucocorticoid antagonist
Purity	>98%
CAS No.	84371-65-3
Molecular Formula	C29H35NO2
Molecular Weight	429.6

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO, and to 50 mM in ethanol
Source	Synthetic
Appearance	Yellow solid
SMILES	CC#CC@@1(CCC@@H2C@@1(CC@@H(C3=C4CCC(=O)C=C4CCC@@H23)C5=CC=C(C=C5)N(C)C)C)O
InChI	InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)
InChIKey	VKHAHZOOUSRJNA-GCNJZUOMSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R60- May impair fertility R61- May cause harm to the unborn child Hazard Phrases: H360 Precautionary Phrases: P201-P308 + P313
Cite This Product	Mifepristone (RU486) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-211)

Alternative Names	(11β,17β)-11-4-(Dimethylamino)phenyl-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one, RU486, RU 38486
Research Areas	Cancer, Apoptosis
PubChem ID	55245
Scientific Background	Mifepristone is a progesterone receptor antagonist used as an abortifacient. It is also an antiglucocorticoid and an antiandrogen. Its relative binding affinity at the progesterone receptor is twice that of progesterone, its affinity at the glucocorticoid receptor is 3x that of dexamethasone, and more than 10 times that of cortisol (1).
References	1. Heikinheim O., Kekkonen R. and Lahteenmaki P. (2003) Contraception. 68(6): 421-426.