NSC59984__p53-MDM2 inhibitor BCX4431 (freebase)
Product Name
NSC59984
Description
p53-MDM2 inhibitor
Purity
>98%
CAS No.
803647-40-7
Molecular Formula
C12H15N3O4
Molecular Weight
265.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (5 mg/ml)
Source
Synthetic
Appearance
Yellow to brown powder
SMILES
CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)N+(=O)O-
InChI
1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
InChIKey
QKTRIGNWBRHBFV-DUXPYHPUSA-N
Safety Phrases
Classification:
D2B Toxic Material Causing Other Toxic Effects – Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
NSC59984 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-542)
Alternative Names
NSC59984, NSC-59984, NSC59984, MLS000737358, SMR000528276, (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one, 803647-40-7, AC1NS9AU, CID 5356520, MLS000737358, 1-Methyl-4-3-(5-nitro-2-furanyl)-1-oxo-2-propenyl-piperazine, 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one
Research Areas
Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID
5356520
Scientific Background
NSC59984 acts on the mutant p53/MDM2 pathway in tumor cells to restore normal function. It is not cytotoxic in healthy cells.
p53-MDM2 inhibitor
D2B Toxic Material Causing Other Toxic Effects – Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.