NSC 663284__Cdc25 Phosphatase inhibitor Pazopanib (Hydrochloride)
Product Name
NSC 663284
Description
Cdc25 Phosphatase inhibitor
Purity
>98% (HPLC)
CAS No.
383907-43-5
Molecular Formula
C15H16ClN3O3
Molecular Weight
321.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Source
Synthetic
Appearance
Red solid
SMILES
C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
InChI
InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChIKey
BMKPVDQDJQWBPD-UHFFFAOYSA-N
Safety Phrases
Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product
NSC 663284 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-520)
Alternative Names
NSC-63284, 6-Chloro-7-2-(4-morpholinyl)ethylamino-5,8-quinolinedione
Research Areas
Cell Signaling
PubChem ID
379077
Scientific Background
NSC 663284 is a potent and selective inhibitor of the CDC25 phosphatase family. Specifically, it has been shown to inhibit CDC25A, CDC25B and CDC25C. NSC 663284 is a cell-permeable and irreversible inhibitor.
References
1. Lazo J.S., et al. (2001) J. Med. Chem. 44(24): 4042–4049.
2. Brisson M., et al. (2005) Mol. Pharm. 68(6): 1810–1820.
Cdc25 Phosphatase inhibitor
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant
2. Brisson M., et al. (2005) Mol. Pharm. 68(6): 1810–1820.