NSC-66811__p53/mdm2 inhibitor Empagliflozin
Product Name
NSC-66811
Description
p53/mdm2 inhibitor
Purity
>98%
CAS No.
6964-62-1
Molecular Formula
C23H20N2O
Molecular Weight
340.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChI
InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChIKey
WEENRMPCSWFMTE-UHFFFAOYSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
NSC-66811 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-338)
Alternative Names
2-Methyl-7-Phenyl(phenylamino)methyl-8-quinolinol, 7-Anilino(phenyl)methyl-2-methylquinolin-8-ol
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID
248986
Scientific Background
A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
References
1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.
p53/mdm2 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes