NVPBEZ235__PI 3-kinase inhibitor Tacrolimus
Product Name
NVPBEZ235
Description
PI 3-kinase inhibitor
Purity
>97%
CAS No.
915019-65-7
Molecular Formula
C30H23N5O
Molecular Weight
469.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/ml at 75 °C), DMSO (1.33 mg/ml), and DMF (10 mg/ml at 75 °C)
Source
Synthetic
Appearance
Crystalline solid
SMILES
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
InChI
InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChIKey
JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Safety Phrases
Classification:
Skin irritation (Category 2)
Eye irritation (Category 2)
Respiratory tract irritation (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302+H312 Harmful if swallowed or in contact with skin.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/attention.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to an approved waste disposal plant.
Cite This Product
NVPBEZ235 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-465)
Alternative Names
4-2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo4,5-cquinolin-1-yl-α,α-dimethyl-benzeneacetonitrile
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
11977753
Scientific Background
NVPBEZ235 is a specific PI 3-kinase (PI3K) tyrosine kinase inhibitor, which shows dual PI3K/mTOR inhibition. NVPBEZ235 has also been shown to inhibit ATR. It has demonstrated antiproliferative activity against tumor cell lines in animal models of cancer.
References
1. Yasumizu Y., et al. (2014) J. Urology. 191(1): 227–234.
2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974.
PI 3-kinase inhibitor
Skin irritation (Category 2)
Eye irritation (Category 2)
Respiratory tract irritation (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302+H312 Harmful if swallowed or in contact with skin.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/attention.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to an approved waste disposal plant.
2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974.