Nicardipine HCl__L-type Ca channel blocker lumateperone (Tosylate)
Product Name
Nicardipine HCl
Description
L-type Ca channel blocker
Purity
>98%
CAS No.
54527-84-3
Molecular Formula
C26H29N3O6•HCl
Molecular Weight
515.99
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water.
Source
Synthetic
Appearance
Yellow solid
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)N+(=O)O-)C(=O)OC.Cl
InChI
InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChIKey
AIKVCUNQWYTVTO-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Risk Phrases:
R23/24/25- Toxic by inhalation, if swallowed and in contact with skin.
Hazard Phrases:
H301-H311-H331
Precautionary Phrases:
P261-P280-P301 + P310-P311
Cite This Product
Nicardipine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-313)
Alternative Names
2-Benzyl(methyl)aminoethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
Research Areas
Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID
41114
Scientific Background
Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud’s phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calcium ions into the cardiac muscle and smooth muscle without changing the serum calcium concentrations.
References
1. Huang R.I., et al. (2006) Catheter Cardiovasc Interv. 68(5): 671-676.
L-type Ca channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Risk Phrases:
R23/24/25- Toxic by inhalation, if swallowed and in contact with skin.
Hazard Phrases:
H301-H311-H331
Precautionary Phrases:
P261-P280-P301 + P310-P311