Nocodazole

Nocodazole__Microtubule inhibitor NT158

Product Name	Nocodazole
Description	Microtubule inhibitor
Purity	>98% (HPLC); NMR (conforms)
CAS No.	31430-18-9
Molecular Formula	C14H11N3O3S
Molecular Weight	301.3

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (10 mg/ml, warm)
Source	Synthetic
Appearance	White to off-white powder.
SMILES	COC(=O)NC1=NC2=C(N1)C=CC(=C2)C(=O)C3=CC=CS3
InChI	InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChIKey	KYRVNWMVYQXFEU-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H341- Suspected of causing genetic defects. H361d – Suspected of damaging the unborn child Precautionary Phrases: P281 – Use personal protective equipment as required.
Cite This Product	Nocodazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-367)

Alternative Names	Methyl (5-2-thienylcarbonyl-1H-benzimidazol-2-yl
Research Areas	Cancer, Apoptosis, Neuroscience
PubChem ID	4122
Scientific Background	Nocodazole also known as Oncodazole. It is an antimitotic agent, associated with the activity of depolymerization of the microtubules (1). Nocadozole has high affinity with Tubulin but little is known on the mechanism of binding. Studies have shown that Nocadozole binds differently to the various α/β isotypes of Tubulin. By measuring the dissociation constants, with the given binding sites, a novel approach of therapeutic agents is under study (2).
References	1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985. 2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.