Okadaic acid__PP1 and PP2A inhibitor ACY-1216
Product Name
Okadaic acid
Description
PP1 and PP2A inhibitor
Purity
>98% (HPLC)
CAS No.
78111-17-8
Molecular Formula
C44H68O13
Molecular Weight
805.0
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in chloroform, ethanol, methanol, acetone or ethyl acetate
Source
Synthetic
Appearance
White crystalline solid
SMILES
C@@45(OC3email protected(Oemail protected(C@@H(O)CC@@H(C2OC@1(OCCCC1)CCemail protected2C)C)C(email protected3O)=C)CC4)Oemail protected(CC5)C=Cemail protected(email protected7OC@6(OC@@H(CCemail protected6O)CC@(O)(C)C(O)=O)C=C(C7)C)C
InChI
InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51
InChIKey
QNDVLZJODHBUFM-WFXQOWMNSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Skin irritation (Category 2), H315
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H315 Causes skin irritation
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P322 Specific measures (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P361 Remove/Take off immediately all contaminated clothing.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product
Okadaic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-521)
Alternative Names
9,10-Deepithio-9,10-didehydroacanthifolicin
Research Areas
Cell Signaling
PubChem ID
446512
Scientific Background
Okadaic acid is a potent and selective inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible inhibitor.
References
1. Cohen P., Holmes C.F., & Tsukitani Y. (1990) Trends Biochem. 15(3): 98–102.
PP1 and PP2A inhibitor
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Skin irritation (Category 2), H315
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H315 Causes skin irritation
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P322 Specific measures (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P361 Remove/Take off immediately all contaminated clothing.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant