P32/98__DPPIV/DPP4 inhibitor Verteporfin
Product Name
P32/98
Description
DPPIV/DPP4 inhibitor
Purity
>98%
CAS No.
136259-20-6
Molecular Formula
C9H18N2OS•0.5C4H4O4
Molecular Weight
260.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in water (20 mg/ml) or DMSO (25 mg/ml)
Source
Synthetic
Appearance
White solid
SMILES
CCC(C)C(C(=O)N1CCSC1)N.C(=CC(=O)O)C(=O)O
InChI
InChI=1S/C9H18N2OS.C4H4O4/c1-3-7(2)8(10)9(12)11-4-5-13-6-11;5-3(6)1-2-4(7)8/h7-8H,3-6,10H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey
ZSOPWZQRZHWYFY-WLHGVMLRSA-N
Safety Phrases
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Cite This Product
P32/98 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-385)
Alternative Names
3-N-((2S,3S)-2-Amino-3-methylpentanoyl-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate
Research Areas
Cell Signaling
PubChem ID
77519185
Scientific Background
P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).
References
1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11.
2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8.
3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94.
4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50.
5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83.
6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50.
7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11.
8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.
DPPIV/DPP4 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8.
3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94.
4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50.
5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83.
6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50.
7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11.
8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.