PK-11195

PK-11195__Benzodiazepine receptor ligand Forodesine (hydrochloride)

Product Name	PK-11195
Description	Benzodiazepine receptor ligand
Purity	>98%
CAS No.	85532-75-8
Molecular Formula	C21H21CIN2O
Molecular Weight	352.86

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 75 mM in ethanol and to 100 mM in DMSO
Source	Synthetic
Appearance	White Crystals
SMILES	CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl
InChI	InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
InChIKey	RAVIZVQZGXBOQO-UHFFFAOYSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed R68- Possible risk of irreversible effects
Cite This Product	PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224)

Alternative Names	N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide
Research Areas	Cancer, Apoptosis
PubChem ID	1345
Scientific Background	PK-11195 is an isoquinoline carboxamide which binds selectively to the peripheral benzodiazepine receptor (PBR). It has a high affinity for the PBR in all species (1). It has also been successfully used in PET scans to visualize brain inflammation in patients with neuronal damage (2).
References	1. Pike V.W., et al. (1993) Nucl Med & Bio. 20(4): 503-525. 2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114.