PP1__Src kinase inhibitor Panobinostat
Product Name
PP1
Description
Src kinase inhibitor
Purity
>98% (TLC)
CAS No.
172889-26-8
Molecular Formula
C16H19N5
Molecular Weight
281.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Source
Synthetic
Appearance
Tan solid
SMILES
CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
InChI
InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 3), H301
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
PP1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-469)
Alternative Names
1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo3,4-dpyrimidin-4-amine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
1400
Scientific Background
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
References
1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701.
2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
Src kinase inhibitor
Acute toxicity, Oral (Category 3), H301
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.