PX 866__PI 3-Kinase inhibitor GSK2795040
Product Name
PX 866
Description
PI 3-Kinase inhibitor
Purity
>98%
CAS No.
502632-66-8
Molecular Formula
C29H35NO8
Molecular Weight
525.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water
Source
Synthetic
Appearance
Crystalline solid
SMILES
CC(=O)OC@@H1CC@2(C@@H(CCC2=O)C3=C1C@4(email protected(OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C
InChI
InChI=1S/C29H35NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20(32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8,14,18-19,21,34H,1-2,9-13,15H2,3-6H3/b17-14+/t18-,19+,21+,
InChIKey
QIUASFSNWYMDFS-NILGECQDSA-N
Safety Phrases
Classification:
Acute Toxicity: Inhalation, Category 4
Acute Toxicity: Oral, Category 4
Acute Toxicity: Skin, Category 4
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H332: Harmful if inhaled.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
Precautionary statements:
P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P321: Specific treatment {see … on this label}.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
Cite This Product
PX 866 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-471)
Alternative Names
(1E,4S,4aR,5R,6aS,9aR)-5-(acetyloxy)-1-(di-2-propen-1-ylamino)methylene-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta5,6naphtho1,2-cpyran-2,7,10(1H)-trione
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
9849735
Scientific Background
PX 866 is a wortmannin derivative that inhibits purified phosphoinositide (PtdIns)-3-kinase and. PX 866 has been shown to inhibit tumor growth by blocking the PI 3-kinase pathway and cell motility.
References
1. Ihle N.T., et al. (2004). Mol. Cancer. Ther. 3(7): 763–772.
2. Gwak H.S., et al. (2011). Int. J. Cancer. 128(4): 787–796.
PI 3-Kinase inhibitor
Acute Toxicity: Inhalation, Category 4
Acute Toxicity: Oral, Category 4
Acute Toxicity: Skin, Category 4
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H332: Harmful if inhaled.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
Precautionary statements:
P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P321: Specific treatment {see … on this label}.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
2. Gwak H.S., et al. (2011). Int. J. Cancer. 128(4): 787–796.