Pazopanib

Pazopanib__Tyrosine kinase inhibitor AMG-338

Product Name Pazopanib
Description

Tyrosine kinase inhibitor

Purity >98%
CAS No. 444731-52-6
Molecular Formula C21H23N7O2S
Molecular Weight 437.5
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO, not in water
Source Synthetic
Appearance White solid powder
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.

Cite This Product Pazopanib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-506)
Alternative Names 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide
Research Areas Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 10113978
Scientific Background Pazopanib is a multi-tyrosine kinase inhibitor. It was approved by the US Food and Drug Administration in 2009. Pazopanib exerted antitumor effects through the inhibition of HGF/c-MET signaling.
References 1. Outani H., et al. (2014) BMC Cancer. 14: 455.
2. Pick A.M., & Nystrom K.K. (2012) Clin. Ther. 34(3): 511–520.