Pifithrin mu__Hsp70 inhibitor Octreotide (acetate)
Product Name
Pifithrin mu
Description
Hsp70 inhibitor
Purity
>98%
CAS No.
64984-31-2
Molecular Formula
C8H7NO2S
Molecular Weight
181.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in ethanol (110 mM) and in DMSO (110 mM)
Source
Synthetic
Appearance
White to off-white solid
SMILES
C1=CC=C(C=C1)C#CS(=O)(=O)N
InChI
InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product
Pifithrin mu (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-325)
Alternative Names
2-Phenylethynesulfonamide, PFTµ
Research Areas
Cancer, Heat Shock
PubChem ID
327653
Scientific Background
Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References
1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.
Hsp70 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338