Piperlongumine__Apoptosis Inducer Nutlin (4a)
Product Name
Piperlongumine
Description
Apoptosis Inducer
Purity
>98%
CAS No.
20069-09-4
Molecular Formula
C17H19NO5
Molecular Weight
317.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in 25 mg/ml DMSO
Source
Synthetic
Appearance
Cream Solid
SMILES
COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O
InChI
InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3
InChIKey
VABYUUZNAVQNPG-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
Cite This Product
Piperlongumine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-156)
Alternative Names
1-(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl-5,6-dihydro-2(1H)-pyridinone
Research Areas
Cancer, Oxidative Stress
PubChem ID
637858
Scientific Background
Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).
References
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199.
2. Raj L., et al. (2011) Nature. 475(7355): 231.
Apoptosis Inducer
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
2. Raj L., et al. (2011) Nature. 475(7355): 231.