Pyr3__TRPC3 Channel blocker Dipraglurant
Product Name
Pyr3
Description
TRPC3 Channel blocker
Purity
>98%
CAS No.
1160514-60-2
Molecular Formula
C16H11Cl3F3N3O3
Molecular Weight
456.63
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
InChI
InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey
RZHGONNSASQOAY-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Pyr3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-306)
Alternative Names
Ethyl 1-{4-(2,3,3-trichloroacryloyl)aminophenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
56964346
Scientific Background
Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
References
1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.
TRPC3 Channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection