R(-)-Gossypol

R(-)-Gossypol__Bcl-2 inhibitor Daun03

Product Name	R(-)-Gossypol
Description	Bcl-2 inhibitor
Purity	>98%
CAS No.	303-45-7
Molecular Formula	C30H30O8
Molecular Weight	518.56

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 25 mM in ethanol and in DMSO.
Source	Synthetic
Appearance	Dark Yellow Solid
SMILES	CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O
InChI	InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(2
InChIKey	QBKSWRVVCFFDOT-UHFFFAOYSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H351 Precautionary Phrases: P281
Cite This Product	R(-)-Gossypol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-223)

Alternative Names	1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol
Research Areas	Cancer, Apoptosis
PubChem ID	3503
Scientific Background	Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2).
References	1. www.bioscreening.net “Gossypol” 2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.