SKF-96365__TRPC channel blocker Taranabant
Product Name
SKF-96365
Description
TRPC channel blocker
Purity
>98%
CAS No.
130495-35-1
Molecular Formula
C22H26N2O3.HCl
Molecular Weight
402.92
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in water
Source
Synthetic
Appearance
White solid
SMILES
COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
InChI
InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4
InChIKey
FWLPKVQUECFKSW-UHFFFAOYSA-N
Safety Phrases
Classification: Irritant. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product
SKF-96365 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-305)
Alternative Names
1-{2-(4-Methoxyphenyl)-2-3-(4-methoxyphenyl)propoxyethyl}-1H-imidazole hydrochloride (1:1)
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
104956
Scientific Background
SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherlial cells (1,3).
References
1. Leis H.J., et al. (1995) Br J Pharmacol. 114(3): 598-601.
2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491.
3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54.
TRPC channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491.
3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54.