SMER3__E3 UB ligase inhibitor Brexpiprazole
Product Name
SMER3
Description
E3 UB ligase inhibitor
Purity
>98%
CAS No.
67200-34-4
Molecular Formula
C11H4N4O2
Molecular Weight
224.18
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 75 mM DMSO
Source
Synthetic
Appearance
Yellow Solid
SMILES
C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
InChI
InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChIKey
SFSSAKVWCKFRHE-UHFFFAOYSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
SMER3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-341)
Alternative Names
9H-Indeno1,2-e1,2,5oxadiazolo3,4-bpyrazin-9-one
Research Areas
Cancer, Apoptosis
PubChem ID
568763
Scientific Background
Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin.
References
1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738.
E3 UB ligase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes