SP600125__Jnk inhibitor AXL1718
Product Name
SP600125
Description
Jnk inhibitor
Purity
>98%
CAS No.
129-56-6
Molecular Formula
C14H8N2O
Molecular Weight
220.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO or methanol
Source
Synthetic
Appearance
Yellow to brown solid
SMILES
C1=CC=C4C3=C1C(=O)C2=CC=CC=C2C3=NNH4
InChI
InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChIKey
ACPOUJIDANTYHO-UHFFFAOYSA-N
Safety Phrases
Classification: D2B – Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation
Precautionary Phrases:
P261 – Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 – Wash skin thoroughly after handling.
P271 – Use only outdoors or in a well-ventilated area.
P280 – Wear protective gloves/ eye protection/ face protection.
P302 + P352 – IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 – IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 – Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 – Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 – If skin irritation occurs: Get medical advice/ attention.
P337 + P313 – If eye irritation persists: Get medical advice/ attention.
P362 – Take off contaminated clothing and wash before reuse.
P403 + P233 – Store in a well – ventilated place. Keep container tightly closed.
P405 – Store locked up.
P501 – Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
SP600125 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-381)
Alternative Names
Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
Research Areas
Cancer, Apoptosis, Cell Signaling
PubChem ID
8515
Scientific Background
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 – 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.
References
1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6.
2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63.
3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204.
4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.
Jnk inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation
Precautionary Phrases:
P261 – Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 – Wash skin thoroughly after handling.
P271 – Use only outdoors or in a well-ventilated area.
P280 – Wear protective gloves/ eye protection/ face protection.
P302 + P352 – IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 – IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 – Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 – Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 – If skin irritation occurs: Get medical advice/ attention.
P337 + P313 – If eye irritation persists: Get medical advice/ attention.
P362 – Take off contaminated clothing and wash before reuse.
P403 + P233 – Store in a well – ventilated place. Keep container tightly closed.
P405 – Store locked up.
P501 – Dispose of contents/ container to an approved waste disposal plant.
2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63.
3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204.
4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.