STF-62247

STF-62247__Autophagy inducer AN-2729

Product Name	STF-62247
Description	Autophagy inducer
Purity	>98%
CAS No.	315702-99-9
Molecular Formula	C15H13N3S
Molecular Weight	267.35

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble in DMSO (26 mg/ml).
Source	Synthetic
Appearance	Solid
SMILES	CC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC=NC=C3
InChI	InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChIKey	KATNUHQNJGNLPW-UHFFFAOYSA-N
Safety Phrases	Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate eye irritant Safety Phrases: S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H319- Causes serious eye irritation. Precautionary statements: P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product	STF-62247 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-396)

Alternative Names	N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Research Areas	Cancer, Autophagy
PubChem ID	704473
Scientific Background	STF-62247 is a selective cell-permeable inducer of autophagy. This is demonstrated by an induction of large vacuole formation in cells. This observation is especially pronounced in von Hippel-Lindau deficient renal carcinoma cells. Induction of autophagy is also seen in vivo in mice.
References	1. Turcotte S., et al. (2008) Autophagy, 4(7): b944-6.