Simvastatin__HMG-CoA reductase inhibitor LDE226
Product Name
Simvastatin
Description
HMG-CoA reductase inhibitor
Purity
>98%
CAS No.
79902-63-9
Molecular Formula
C25H38O5
Molecular Weight
418.57
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 75 mM in ethanol and 50 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
CCC(C)(C)C(=O)Oemail protected1Cemail protected(C=C2email protected1email protected(email protected(C=C2)C)CCC@@H3Cemail protected(CC(=O)O3)O)C
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15
InChIKey
RYMZZMVNJRMUDD-HGQWONQESA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Cite This Product
Simvastatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-257)
Alternative Names
(1S,3R,7S,8S,8aR)-8-{2-(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-ylethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate
Research Areas
Cancer, Apoptosis
PubChem ID
54454
Scientific Background
Simvastatin is a member of the drug class of statins, used for lowering cholersterol, thereby preventing cardiovascular disease. They have a powerful inhibitory effect on HMG-CoA reducatse (1).
References
1. Alberts A.W. (1998) Am J Cardio. 62(15): 10J-15J.
HMG-CoA reductase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility