Sirtinol__SIRT inhibitor Mivebresib
Product Name
Sirtinol
Description
SIRT inhibitor
Purity
>98%
CAS No.
410536-97-9
Molecular Formula
C26H22N2O2
Molecular Weight
394.47
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
Off-white to yellow crystals
SMILES
C@@H(NC(=O)C1=CC=CC=C1NC=C/3C2=CC=CC=C2C=CC3=O)(C4=CC=CC=C4)C
InChI
InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17-
InChIKey
YUGODMKHHCZZOI-QJOMJCCJSA-N
Safety Phrases
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Sirtinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-360)
Alternative Names
2-(2-Hydroxy-1-naphthalenyl)methyleneamino-N-(1-phenylethyl)benzamide
Research Areas
Cell Signaling, Epigenetics
PubChem ID
5717148
Scientific Background
Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
References
1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837.
2. Mai A., et al (2005) J.Med.Chem. 48: 7789.
3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.
4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.
SIRT inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Mai A., et al (2005) J.Med.Chem. 48: 7789.
3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364.
4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.