Tamoxifen Citrate__Autophagy inducer GLPG0635
Product Name
Tamoxifen Citrate
Description
Autophagy inducer
Purity
>99%
CAS No.
54965-24-1
Molecular Formula
C26H29NO•C6H8O7
Molecular Weight
563.65
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in methanol (50 mg/ml) or ethanol; very slightly soluble in water or acetone.
Source
Synthetic
Appearance
White to off-white powder
SMILES
C(C(O)(C(=O)O)CC(=O)O)C(=O)O.C3=C(C(=C(C1=CC=CC=C1)CC)C2=CC=CC=C2)C=CC(=C3)OCCN(C)C
InChI
InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b
InChIKey
FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Safety Phrases
Classification: D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen, Carcinogen, Reproductive hazard
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
H360- May damage fertility or the unborn child.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Cite This Product
Tamoxifen Citrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-389)
Alternative Names
(2)-2-4-(1,2-Diphenyl-1-butenyl)phenoxy-N,N-dimethylethanamine citrate
Research Areas
Cancer, Autophagy
PubChem ID
2733525
Scientific Background
Tamoxifen citrate is an endocrine therapy drug used to treat breast cancer. It acts to interrupt estrogen signaling by blocking the estrogen receptor (ER). In vivo, tamoxifen and tamoxafin metabolites bind to estrogen receptors, causing the transcription of estrogen-response genes to be inhibited. In vitro, Tamoxifen is known to inhibit protein kinase C through estrogen receptor-independent antineoplastic effects. This drug therefore has important applications in breast cancer research, particularly in ER+ breast cancers. Recent studies have shown tamoxifen-resistant cells use autophagy as a survival mechanism.
References
1. Thomas, S. et al. (2011). Breast Cancer Res Treat, 130(2): 437-47.
2. Ma, J. et al. (2014). BMC Cancer, 14: 172.
3. Patel, S. et al. (2012). Int J Radiat Oncol Biol Phys, 82(2): 739-42.
4. Wang, D. et al. (2004). Mol Endocrinol. 402-11.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
H360- May damage fertility or the unborn child.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
2. Ma, J. et al. (2014). BMC Cancer, 14: 172.
3. Patel, S. et al. (2012). Int J Radiat Oncol Biol Phys, 82(2): 739-42.
4. Wang, D. et al. (2004). Mol Endocrinol. 402-11.