Taxol

Taxol__Microtubule stabilizer JNK-IN-8

Product Name	Taxol
Description	Microtubule stabilizer
Purity	>98% (TLC); NMR (Conforms)
CAS No.	33069-62-4
Molecular Formula	C47H51NO14
Molecular Weight	853.9

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble in DMSO, ethanol or acetonitrile
Source	Synthetic
Appearance	White solid
SMILES	CC1=C2C@@(C@(email protected(C@@H3C@4(email protected(OC4)CC@@H(C@3(C(=O)C@@H2OC(=O)C)C)O)OC(=O)C)OC(=O)C5=CC=CC=C5)(CC@@H1OC(=O)email protected(O)C@@H(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)(C)C
InChI	InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-
InChIKey	RCINICONZNJXQF-MZXODVADSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H318-H361f-H341-H332-H312-H302-H335-H315-H334-H317 Precautionary Phrases: P280-P305+P351+P338-P260-P261-P342+P311
Cite This Product	Taxol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-239)

Alternative Names	(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyloxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Paclitaxel
Research Areas	Cancer, Apoptosis
PubChem ID	36314
Scientific Background	Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2).
References	1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327. 2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067.