Temozolomide__AGT inhibitor SCH900777
Product Name
Temozolomide
Description
AGT inhibitor
Purity
>99% (TLC); NMR(Conforms)
CAS No.
85622-93-1
Molecular Formula
C6H6N6O2
Molecular Weight
194.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (25 mg/ml, warm) or water (weakly)
Source
Synthetic
Appearance
Off white powder
SMILES
CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
InChI
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChIKey
BPEGJWRSRHCHSN-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H350 May cause cancer.
H360 May damage fertility or the unborn child.
Precautionary Phrases:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice or attention.
Cite This Product
Temozolomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-363)
Alternative Names
3-Methyl-4-oxo-3,4-dihydroimidazo5,1-d1,2,3,5tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo5,1-d-1,2,3,5-tetrazin-4(3H)-one
Research Areas
Cancer, Apoptosis
PubChem ID
5394
Scientific Background
Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4).
References
1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515.
2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463.
3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13.
4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.
AGT inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H350 May cause cancer.
H360 May damage fertility or the unborn child.
Precautionary Phrases:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice or attention.
2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463.
3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13.
4. Natsumeda M., et al. (2011) Neuropathology. 31: 486.