Terazosin Hydrochloride__Alpha adrenergic antagonist, and Hsp90 Activator Lenalidomide
Product Name
Terazosin Hydrochloride
Description
Alpha adrenergic antagonist, and Hsp90 Activator
Purity
>98%
CAS No.
63074-08-8
Molecular Formula
C19H25N5O4·HCl
Molecular Weight
423.89
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Antagonist
Solubility
Soluble to 20mg/ml in warm water
Source
Synthetic
Appearance
White to off-white solid
SMILES
C1=C(OC)C(=CC2=C1C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.Cl-.O
InChI
InChI=1S/C19H25N5O4.ClH.H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;/h10-11,1
InChIKey
MWYNOTLRCUQCKD-UHFFFAOYSA-M
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. Hazard Statements: H302 – Harmful if swallowed.
Cite This Product
Terazosin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-516)
Alternative Names
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furanyl)carbonylpiperazine
Research Areas
Cancer, Alpha-2 Adrenergic Receptors, Apoptosis, Neuroscience, Neurotransmitter Receptors
PubChem ID
44383
Scientific Background
Terazosin (TZ) which is marketed as an alpha1-adrenergic receptor antagonist, has been shown to alleviate organ damaged and increase survival in rodent models of sepsis and stroke in vivo (1). It inhibits apoptosis in macrophages by activation of Pgk1 and Hsp90 (1).
References
1. Chen X., et al. (2015) Nature Chem Biol. 11:19-25.
2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863.
3. Kyncl J.J. (1986) Am J Med. 80:12.
Alpha adrenergic antagonist, and Hsp90 Activator
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. Hazard Statements: H302 – Harmful if swallowed.
2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863.
3. Kyncl J.J. (1986) Am J Med. 80:12.