Thalidomide__E3 UB ligase inhibitor A-1210478
Product Name
Thalidomide
Description
E3 UB ligase inhibitor
Purity
>98%
CAS No.
50-35-1
Molecular Formula
C13H10N2O4
Molecular Weight
258.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 5 mg/ml DMSO
Source
Synthetic
Appearance
White Solid
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChI
InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChIKey
UEJJHQNACJXSKW-UHFFFAOYSA-N
Safety Phrases
Classification: Very toxic material causing immediate and serious toxic effects. Highly toxic teratogen.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
H360 – May damage fertility or the unborn child
Precautionary Statements:
P201 – Obtain special instructions before use.
P308 + P313 – If exposed or concerned: Get medical advice/ attention.
Cite This Product
Thalidomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-336)
Alternative Names
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, N-(2,6-dioxo-3-piperidinyl)phthalimide
Research Areas
Cancer, Apoptosis
PubChem ID
5426
Scientific Background
Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.
References
1. Ito T., et al. (2010) Science. 327:1345.
2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195.
3. D’Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.
E3 UB ligase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
H360 – May damage fertility or the unborn child
Precautionary Statements:
P201 – Obtain special instructions before use.
P308 + P313 – If exposed or concerned: Get medical advice/ attention.
2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195.
3. D’Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.