Thiolutin__RNA polymerase inhibitor GSK2126459
Product Name
Thiolutin
Description
RNA polymerase inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
87-11-6
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (15 mg/ml)
Source
Synthetic
Appearance
Yellow powder
SMILES
CC(=O)NC1=C2C(=CSS2)N(C1=O)C
InChI
InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
InChIKey
MHMRAFONCSQAIA-UHFFFAOYSA-N
Safety Phrases
Classification: Danger.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H300 – Fatal if swallowed
H330 – Fatal if inhaled
Precautionary Phrases:
P260 – Do not breathe dust/fume/gas/mist/vapours/spray
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P405 – Store locked up
Cite This Product
Thiolutin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-375)
Alternative Names
N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo4,3-bpyrrol-6-yl)acetamide
Research Areas
Cell Signaling, Epigenetics
PubChem ID
6870
Scientific Background
Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.
References
1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92.
2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165.
3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.
RNA polymerase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H300 – Fatal if swallowed
H330 – Fatal if inhaled
Precautionary Phrases:
P260 – Do not breathe dust/fume/gas/mist/vapours/spray
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P405 – Store locked up
2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165.
3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.