Tranilast__Angiogenesis inhibitor L-685459
Product Name
Tranilast
Description
Angiogenesis inhibitor
Purity
>95% (HPLC)
CAS No.
53902-12-8
Molecular Formula
C18H17NO5
Molecular Weight
327.33
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO.
Source
Synthetic
Appearance
Off-white to yellow powder.
SMILES
COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
InChI
InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 – Harmful if swallowed.
H312 – Harmful in contact with skin.
H332 – Harmful if inhaled.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.
Cite This Product
Tranilast (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-369)
Alternative Names
2-{(2E)-3-(3,4-dimethoxyphenyl)prop-2- enoylamino}benzoic acid
Research Areas
Cancer, Cardiovascular System, Cell Signaling, Neuroscience
PubChem ID
5282230
Scientific Background
Tranilast is an antiallergic, antifibrotic drug that inhibits collagen synthesis, when administered in a dose –dependent manner for a 48 h treatment (1). As an antifibrotic agent, studies shown an effect on the growth of metastasis of mammary carcinoma. It is associated with the inhibition of the growth factor –beta. (TGF-beta) (2).
References
1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897.
2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.
Angiogenesis inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 – Harmful if swallowed.
H312 – Harmful in contact with skin.
H332 – Harmful if inhaled.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.
2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.