VU0467154__M4 Receptor Agonist Opicapone
Product Name
VU0467154
Description
M4 Receptor Agonist
Purity
95.11%
CAS No.
1451993-15-9
Molecular Formula
C17H15F3N4O3S2
Molecular Weight
444.45
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
Tan Solid
SMILES
O=S(C1=CC=C(C=C1)CNC(C2=C(N)C 3=C(C)C(C)=NN=C3S2)=O)(C(F)(F)F)= O
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
VU0467154 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-184)
Alternative Names
5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno2,3-cpyridazine-6-carboxamide
Research Areas
Neurodegeneration, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID
PMC4324418
Scientific Background
Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
References
1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 – 942.
M4 Receptor Agonist
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection