Vinblastine sulfate__Cell cycle blocker AMG 234
Product Name
Vinblastine sulfate
Description
Cell cycle blocker
Purity
>98%
CAS No.
143-67-9
Molecular Formula
C46H58N4O9•H2SO4
Molecular Weight
909.1
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO, methanol or water (25 mg/ml).
Source
Synthetic
Appearance
White powder.
SMILES
C@@178C@@H(N(C2=C1C=C(C(=C2)OC)C@@5(C3=C(C4=C(NH3)C=CC=C4)CCN6CC@@H(C5)CC@(O)(C6)CC)C(OC)=O)C)C@(O)(email protected(OC
InChI
InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)
InChIKey
KDQAABAKXDWYSZ-PNYVAJAMSA-N
Safety Phrases
Classification: D1B- Toxic Material Causing Immediate and Serious Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant, Mutagen
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H315- Causes skin irritation.
H318- Causes serious eye damage.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P280- Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
Vinblastine sulfate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-407)
Alternative Names
Vincaleukoblastine
Research Areas
Cancer, Autophagy
PubChem ID
5388983
Scientific Background
Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with lysosomes.
References
1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46.
2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65.
Cell cycle blocker
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H315- Causes skin irritation.
H318- Causes serious eye damage.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P280- Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65.