WP-1130__DUB inhibitor SLx-2121
Product Name
WP-1130
Description
DUB inhibitor
Purity
>98%
CAS No.
856243-80-6
Molecular Formula
C19H18BrN3O
Molecular Weight
384.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol
Source
Synthetic
Appearance
Pale Yellow Solid
SMILES
CCCC@@H(C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
InChI
InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
InChIKey
LIDOPKHSVQTSJY-VMEIHUARSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
WP-1130 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-337)
Alternative Names
(2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
Research Areas
Cancer, Apoptosis
PubChem ID
11222830
Scientific Background
A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination.
References
1. KapuriaV., et al. (2010) Cancer Res. 70: 9265.
2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.
DUB inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.