Wortmannin__Autophagy inhibitor AV-414
Product Name
Wortmannin
Description
Autophagy inhibitor
Purity
>98%
CAS No.
19545-26-7
Molecular Formula
C23H24O8
Molecular Weight
428.44
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
Source
Synthetic
Appearance
White to off-white solid.
SMILES
C@@15(C4=C(C(C2=C1C@@H(CC@3(email protected2CCC3=O)C)OC(=O)C)=O)OC=C4C(OC@@H5COC)=O)C
InChI
InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
InChIKey
QDLHCMPXEPAAMD-QAIWCSMKSA-N
Safety Phrases
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, Highly toxic by skin absorption
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300 + H310- Fatal if swallowed or in contact with skin
H330- Fatal if inhaled.
Precautionary statements:
P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash hands thoroughly after handling.
P280- Wear protective gloves/ protective clothing.
P284- Wear respiratory protection.
P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water.
P310- Immediately call a POISON CENTER or doctor/ physician.
Cite This Product
Wortmannin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-392)
Alternative Names
SL-2052, KY12420
Research Areas
Cancer, Autophagy
PubChem ID
312145
Scientific Background
Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
References
1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23.
2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61.
3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4.
4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300 + H310- Fatal if swallowed or in contact with skin
H330- Fatal if inhaled.
Precautionary statements:
P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash hands thoroughly after handling.
P280- Wear protective gloves/ protective clothing.
P284- Wear respiratory protection.
P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water.
P310- Immediately call a POISON CENTER or doctor/ physician.
2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61.
3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4.
4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.