Xanthohumol__Autophagy inhibitor ALW-II-41-29
Product Name
Xanthohumol
Description
Autophagy inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
6754-58-1
Molecular Formula
C21H22O5
Molecular Weight
354.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O)C
InChI
InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChIKey
ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Safety Phrases
Classification: Toxic
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H317 May cause an allergic skin reaction.
H400 Very toxic to aquatic life.
Precautionary Phrases:
P273 Avoid release to the environment.
P280 Wear protective gloves.
Cite This Product
Xanthohumol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-370)
Alternative Names
(2E)-1-2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl-3-(4-hydroxyphenyl)-2-propen-1-one
Research Areas
Cancer, Autophagy
PubChem ID
639665
Scientific Background
Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).
References
1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900.
2. Vene R., et al. (2012) Mol. Med. 18: 1292.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H317 May cause an allergic skin reaction.
H400 Very toxic to aquatic life.
Precautionary Phrases:
P273 Avoid release to the environment.
P280 Wear protective gloves.
2. Vene R., et al. (2012) Mol. Med. 18: 1292.