YM-08__Hsp70 Inhibitor LGK976
Product Name
YM-08
Description
Hsp70 Inhibitor
Purity
>99% (HPLC)
Molecular Formula
C19H17N3OS2
Molecular Weight
367.49
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
Yellow-orange solid
SMILES
O=C2C(SC(=Cc1ncccc1)N2CC)=C3Sc4ccccc4N3C
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
YM-08 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-122)
Alternative Names
(2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
Research Areas
Cancer, Heat Shock
Scientific Background
YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References
1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g
Hsp70 Inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection