Y 27632__ROCK kinase inhibitor AF38471
Product Name
Y 27632
Description
ROCK kinase inhibitor
Purity
>98% (HPLC)
CAS No.
146986-50-7
Molecular Formula
C14H23Cl2N3O
Molecular Weight
320.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (<1 mg/ml), dioxan (<1 mg/ml), water (very soluble
Source
Synthetic
Appearance
White to pale yellow powder
SMILES
CC@@H(N)email protected1CCC@@H(CC1)C(=O)NC2=CC=NC=C2.Cl.Cl
InChI
InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1
InChIKey
IYOZTVGMEWJPKR-VOMCLLRMSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P322 Specific measures (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
Y 27632 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-486)
Alternative Names
Y-27632 dihydrochloride, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
448042
Scientific Background
Y 27632 is a very potent and selective ROCK1 and ROCK2 inhibitor. Y 27632 is cell permeable and is an ATP competitive inhibitor.
References
1. Shi J., et al. (2013) Cell Death & Disease, 4: e483.
ROCK kinase inhibitor
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P322 Specific measures (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/ container to an approved waste disposal plant.