ZM 336372__c-Raf kinase inhibitor HG-9-91-03
Product Name
ZM 336372
Description
c-Raf kinase inhibitor
Purity
>95% (HPLC)
CAS No.
208260-29-1
Molecular Formula
C23H23N3O3
Molecular Weight
389.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (200 mg/ml)
Source
Synthetic
Appearance
White to off-white solid
SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O
InChI
InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChIKey
PYEFPDQFAZNXLI-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 5)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H303 May be harmful if swallowed.
Cite This Product
ZM 336372 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-488)
Alternative Names
N-5-(3-Dimethylaminobenzamido)-2-methylphenyl-4-hydroxybenzamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5730
Scientific Background
ZM 336372 is a potent, specific and reversible inhibitor of the protein kinase c-Raf. It has also been shown to inhibit SAPK2/p38. ZM 336372 is cell permeable.
References
1. Hall-Jackson C.A., et al. (1999) Chem. Biol. 6(8): 559–568.
c-Raf kinase inhibitor
Acute toxicity, Oral (Category 5)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H303 May be harmful if swallowed.