Zerumbone__NF-κB kinase inhibitor MK-4829 (tosylate)
Product Name
Zerumbone
Description
NF-κB kinase inhibitor
Purity
>98%
CAS No.
471-05-6
Molecular Formula
C15H22O
Molecular Weight
218.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (≥10 mg/ml)
Source
Synthetic
Appearance
White to off-white solid
SMILES
C/C/1=CCC(/C=C/C(=O)/C(=C/CC1)/C)(C)C
InChI
InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+
InChIKey
GIHNTRQPEMKFKO-SKTNYSRSSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Zerumbone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-265)
Alternative Names
(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one
Research Areas
Cancer, Apoptosis
PubChem ID
5470187
Scientific Background
Potentiates TRAIL-induced apoptosis via upregulation of death receptor DR4 and DR5 expression. Has no cytotoxic effect on normal cells. Cell permeable. Natural sesquiterpene ketone isolated from Zingiber sp.
References
1. Leu J.L., et al. (2009) Mol Cell. 36:15.
NF-κB kinase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection