IU1__Usp-14 inhibitor PSI-7977
Product Name
IU1
Description
Usp-14 inhibitor
Purity
>98%
CAS No.
314245-33-5
Molecular Formula
C18H21FN2O
Molecular Weight
300.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 30 mg/ml DMSO, 15 mg/ml Ethanol
Source
Synthetic
Appearance
Beige Solid
SMILES
CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
InChI
InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
InChIKey
JUWDSDKJBMFLHE-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H303 – May be harmful if swallowed
H318 – Causes serious eye damage
Precautionary Statements:
P280 – Wear protective gloves/ eye protection/ face protection
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses.
Cite This Product
IU1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-329)
Alternative Names
1-1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl-2-pyrrolidin-1-yl-ethanone
Research Areas
Cancer, Apoptosis
PubChem ID
675434
Scientific Background
Selective inhibitor of Usp14 (IC50<4 M). Enhances proteasome activity and substrate proteolysis. Cell permeable.
References
1. Lee B.H., et al. (2010) Nature 467: 1179.
2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871.
Usp-14 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H303 – May be harmful if swallowed
H318 – Causes serious eye damage
Precautionary Statements:
P280 – Wear protective gloves/ eye protection/ face protection
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses.
2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871.